Sulindac

Known as: Sulindac [Chemical/Ingredient], 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-, (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid 
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing adenomas… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Familial adenomatous polyposis is caused by a germ-line mutation in the adenomatous polyposis coli gene and is… (More)
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Highly Cited
2000
Highly Cited
2000
The short-chain fatty acid butyrate, produced by microbial fermentation of dietary fiber in the large intestine, is a… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND & AIMS 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (HRIs) were found incidentally to reduce… (More)
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Highly Cited
1997
Highly Cited
1997
Recent evidence supports the theory that tumor growth in vivo depends on evasion of normal homeostatic control mechanisms that… (More)
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Highly Cited
1996
Highly Cited
1996
Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2… (More)
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Highly Cited
1996
Highly Cited
1996
The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis. To test… (More)
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Highly Cited
1995
Highly Cited
1995
Epidemiological and laboratory animal model studies have suggested that nonsteroidal anti-inflammatory drugs reduce the risk of… (More)
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Highly Cited
1991
Highly Cited
1991
In familial adenomatous polyposis, sulindac-induced polyp regression has been reported by several authors. In this study, the… (More)
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Highly Cited
1983
Highly Cited
1983
Four members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti-inflammatory drugs. Three… (More)
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