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Sulindac

Known as: Sulindac [Chemical/Ingredient], 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-, (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid 
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Abstract Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing… Expand
Highly Cited
2002
Highly Cited
2002
BACKGROUND Familial adenomatous polyposis is caused by a germ-line mutation in the adenomatous polyposis coli gene and is… Expand
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Highly Cited
2001
Highly Cited
2001
Epidemiological studies have documented a reduced prevalence of Alzheimer's disease among users of nonsteroidal anti-inflammatory… Expand
Highly Cited
1999
Highly Cited
1999
PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC… Expand
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Highly Cited
1996
Highly Cited
1996
Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2… Expand
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Highly Cited
1995
Highly Cited
1995
Several studies indicate that nonsteroidal anti-inflammatory drugs including indomethacin, aspirin, sulindac, and piroxicam… Expand
Highly Cited
1993
Highly Cited
1993
BACKGROUND Familial adenomatous polyposis is an autosomal dominant disorder characterized by the formation of hundreds of… Expand
Highly Cited
1991
Highly Cited
1991
In familial adenomatous polyposis, sulindac-induced polyp regression has been reported by several authors. In this study, the… Expand
Highly Cited
1989
Highly Cited
1989
The effect of sulindac, a nonsteroid antiinflammatory drug, on colon polyposis has been evaluated in seven patients after… Expand
Highly Cited
1983
Highly Cited
1983
Four members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti‐inflammatory drugs. Three… Expand