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Sulindac

Known as: Sulindac [Chemical/Ingredient], 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-, (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid 
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (17)

AclinApo-SulinClinorilCopal

Broader (3)

Anti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsCyclooxygenase Inhibitors
Arthritis, GoutyDegenerative polyarthritisDrug AllergyIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Cyclooxygenases in cancer: progress and perspective.
Highly Cited
2003
Highly Cited
2003
Novel IKK inhibitors: β-carbolines
Review
2002
Review
2002
Green tea: cancer preventive beverage and/or drug.
Highly Cited
1999
Highly Cited
1999
Green tea and cancer chemoprevention.
Highly Cited
1997
Highly Cited
1997
Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion.
Recent evidence supports the theory that tumor growth in vivo depends on evasion of normal homeostatic control mechanisms that… 
Review
1997
Review
1997
Nonsteroidal anti-inflammatory drugs and colorectal cancer: evolving concepts of their chemopreventive actions.
Review
1996
Review
1996
Self-Promotion? Intimate Connections Between APC and Prostaglandin H Synthase-2
Highly Cited
1995
Highly Cited
1995
Attenuated familial adenomatous polyposis (AFAP) a phenotypically and genotypically distinctive variant of FAP
Background. The usual manifestation of familial adenomatous polyposis (FAP) is hundreds or thousands of colonic adenomas. The… 
Highly Cited
1984
Highly Cited
1984
Effects of sulindac and ibuprofen in patients with chronic glomerular disease. Evidence for the dependence of renal function on prostacyclin.
We investigated whether the glomerular synthesis of prostacyclin modulates the renal blood flow and glomerular filtration rate in… 
Highly Cited
1984
Highly Cited
1984
Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial…
Selective nutritive conditions were used to isolate normal epithelial cells from fibroblasts in primary cell cultures prepared… 
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