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Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability… Expand RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome… Expand Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide… Expand Geneticists study the gene; however, for epigeneticists, there is no obvious 'epigene'. Nevertheless, during the past year, more… Expand Epigenetics has recently evolved from a collection of diverse phenomena to a defined and far-reaching field of study. In this… Expand Epigenetic mechanisms, which involve DNA and histone modifications, result in the heritable silencing of genes without a change… Expand Cells of a multicellular organism are genetically homogeneous but structurally and functionally heterogeneous owing to the… Expand The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression… Expand Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia and include genome-wide losses of, and… Expand This report describes the establishment directly from normal preimplantation mouse embryos of a cell line that forms… Expand