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statine

Known as: 4-amino-3-hydroxy-6-methylheptanoic acid 
National Institutes of Health

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Amino Acids

Papers overview

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2008
2008
A simple microscale method for determining the relative stereochemistry of statine units.
A simple method to determine the relative stereochemistry of statine amino acids (gamma-amino-beta-hydroxyacids) by using (1)H… 
2007
2007
Macrocyclic Statine‐Based Inhibitors of BACE‐1
Minimal sequence requirements for binding of substrate‐derived statine peptides to the aspartyl enzyme were established on the… 
1990
1990
The selectivity of statine-based inhibitors against various human aspartic proteinases.
The interactions of five human enzymes (renin, pepsin, gastricsin, cathepsin D and cathepsin E) and the aspartic proteinase from… 
1988
1988
Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.
Two new inhibitors, 4 and 5, of the aspartic proteinase porcine pepsin were synthesized. These compounds, which span the P4-P'3… 
1987
1987
Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site.
Substituted 1,3- and 1,4-diamines were prepared from epoxides derived from Boc-leucine or Boc-cyclohexylalanine. These diamines… 
1986
1986
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin.
Five new cathepsin D inhibitors were synthesized and tested as inhibitors of bovine cathepsin D. The compounds were derived by… 
Highly Cited
1985
Highly Cited
1985
Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.
Analogues of the renin octapeptide substrate were synthesized in which replacement of the scissile dipeptide with (3S,4S)-4-amino… 
Highly Cited
1985
Highly Cited
1985
Inhibition of aspartic proteases by pepstatin and 3-methylstatine derivatives of pepstatin. Evidence for collected-substrate enzyme inhibition.
The synthesis of 10 analogues of pepstatin modified so that statine is replaced by 4-amino-3-hydroxy-3,6-dimethylheptanoic acid… 
Highly Cited
1984
Highly Cited
1984
Statine-containing renin inhibitor. Dissociation of blood pressure lowering and renin inhibition in sodium-deficient dogs.
Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 is a new, potent, specific statine -containing renin inhibitor. In vitro, the ID50 needed to… 
1973
1973
Letter: X-ray structure determination of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin.
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