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Why do some organisms use a urea-methylamine mixture as osmolyte? Thermodynamic compensation of urea and trimethylamine N-oxide interactions with protein.
TLDR
Measurements have shown that the presence of TMAO has no effect on the interaction of urea with the protein in either the native or the unfolded (reduced carboxymethylated RNase T1) state, and the effects of the two cosolvents on the transition temperature were found to be essentially the algebraic sum of their effects when used individually.
Cloning and functional characterization of a constitutively expressed nitrate transporter gene, OsNRT1, from rice.
TLDR
Northern-blot and in situ hybridization analysis indicated that OsNRT1 is constitutively expressed in the most external layer of the root, epidermis and root hair, which strongly indicate that OsnRT1 encodes a constitutive component of a low-affinity nitrate uptake system for rice.
Outbreak ofCandida parapsilosis fungemia in neonatal intensive care units: Clinical implications and genotyping analysis
TLDR
The results suggest that C. parapsilosis fungemia increases the morbidity and mortality of neonates but does not cause acute lethal events, and was caused by two main genotypes, possibly via cross-infection by the hands of health care workers.
Contribution of the surface free energy perturbation to protein-solvent interactions.
TLDR
A correlation was found for both BSA and lysozyme in KAsp, NaGlu, LysHCl, ArgGlu and LysGlu between the surface tension effect and the observed preferential interactions, indicating that the change in the surface free energy of the protein-containing cavity due to thesurface tension increase for water by these amino acid salts contributes dominantly to the observed increase in the chemical potential of theprotein by their addition.
Urea dependence of thiol-disulfide equilibria in thioredoxin: confirmation of the linkage relationship and a sensitive assay for structure.
TLDR
The urea dependence of thiol-disulfide equilibria provides a sensitive assay for folded structure in peptides or proteins and should also be useful to evaluate the stabilizing or destabilizing effect of natural or genetically engineered disulfides in proteins.
Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or α-linolenic acids
TLDR
The increased mass of PC in heart was coincident with a decrease in the mass of phosphatidylethanolamine, suggesting that 22∶6n−3 induced PC synthesis by increasing phosphorus-N-methyltransferase activity in the heart.
Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases.
  • S. Lu, W. Lu, M. Laskowski
  • Biology
    Proceedings of the National Academy of Sciences…
  • 13 February 2001
TLDR
An additivity-based sequence to reactivity algorithm for the interaction of members of the Kazal family of protein inhibitors with six selected serine proteinases is described and is exceptionally fast so that all possible sequences can be predicted.
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