Skip to search formSkip to main contentSkip to account menu

squalene synthase activity

Known as: squalene synthetase activity 
Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate. [EC:2.5.1.21]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
W12-P-074 Inhibition of squalene synthase activity and lipid biosynthesis by EP2306 and EP2302, two novel 2-biphenylmorpholine compounds
1995
1995
Inhibition of Mammalian Squalene Synthetase Activity by Zaragozic Acid A Is a Result of Competitive Inhibition Followed by Mechanism-based Irreversible Inactivation
Squalene synthetase (SQS, EC 2.5.1.21) catalyzes the first committed step in the formation of cholesterol and thus represents an… 
1992
1992
Solubilization, partial purification, and immunodetection of squalene synthetase from tobacco cell suspension cultures.
Squalene synthetase, an integral membrane protein and the first committed enzyme for sterol biosynthesis, was solubilized and… 
1992
1992
Subcellular localization of squalene synthase in human hepatoma cell line Hep G2.
1991
1991
Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase
SummaryThe ERG9 gene of Saccharomyces cerevisiae has been cloned by complementation of the erg9-1 mutation which affects squalene… 
1989
1989
Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols.
1986
1986
Regulation of squalene synthetase activity in rat liver: elevation by cholestyramine, but no diurnal variation.
1982
1982
The role of squalene synthetase in the inhibition of tetrahymanol biosynthesis by cholesterol inTetrahymena pyriformis
The biosynthesis of the triterpenoid alcohol tetrahymanol byTetrahymena pyriformis is rapidly inhibited by the addition of… 
Highly Cited
1979
Highly Cited
1979
Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor.
Squalene synthetase (farnesyltransferase; farnesyl diphosphate:farnesyl-diphosphate farnesyltransferase, EC 2.5.1.21), the enzyme… 
1975
1975
Adenosine 5'-triphosphate stimulation of the activity of a partially purified phytoene synthetase complex.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)