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A lethal defect of mitochondrial and peroxisomal fission.

We report on a newborn girl with microcephaly, abnormal brain development, optic atrophy and hypoplasia, persistent lactic acidemia, and a mildly elevated plasma concentration of very-long-chain…
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Analysis of the Carboxyl-terminal Peroxisomal Targeting Signal 1 in a Homologous Context in Saccharomyces cerevisiae*

TLDR
It is shown that dimerization of MDH3 precedes import into the organelle, which suggests that additional domains in the protein may be of decisive importance whether or not a certain PTS1 variant is recognized by the components of the peroxisomal import machinery.
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The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy

TLDR
In insight into the pathway underlying the elevated levels of C26:0 in X‐ALD, ELOVL1 (elongation of very‐long‐chain‐fatty acids) is identified as the single elongase catalysing the synthesis of both saturated VLCFA (C 26:0) and mono‐unsaturated VLC FA (C26:1).
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Molecular characterization of carnitine‐dependent transport of acetyl‐CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter,…

TLDR
In Saccharomyces cerevisiae, β‐oxidation of fatty acids is confined to peroxisomes, and the genes for the yeast orthologue of the human mitochondrial carnitine acylcarnitine translocase (YOR100C or CAC) and for a transport protein (AGP2) required for carn itine transport across the plasma membrane are identified.
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Peroxisomal fatty acid alpha- and beta-oxidation in humans: enzymology, peroxisomal metabolite transporters and peroxisomal diseases.

TLDR
The current state of knowledge about peroxisomal fatty acid alpha- and beta-oxidation is described with particular emphasis on the substrates Beta-oxidized inperoxisomes.
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Peroxisomal Fatty Acid β-Oxidation Is Not Essential for Virulence of Candida albicans

TLDR
The data suggest that peroxisomal fatty acid β-oxidation is not essential for virulence of C. albicans, implying that the attenuated virulent of the fox2Δ/fox2ΓΔ mutant is largely due to a dysfunctional glyoxylate cycle.
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Metabolite transport across the peroxisomal membrane.

TLDR
The current state of knowledge of the permeability properties of the peroxisomal membrane is described and several half-ABC (ATP-binding cassette) transporters which may be present as hetero- and homo-dimers are described.
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Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

TLDR
The authors systematically identify the landscape of cellular contact sites in yeast, discovering four potential novel contact sites and two tether proteins for the peroxisome-mitochondria contact site.
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Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids

TLDR
CTS, and most likely the other ABCD family members, represent rare examples of polytopic membrane proteins with an intrinsic additional enzymatic function that may regulate the entry of substrates into the β-oxidation pathway.
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The Arabidopsis Peroxisomal ABC Transporter, Comatose, Complements the Saccharomyces cerevisiae pxa1 pxa2Δ Mutant for Metabolism of Long-chain Fatty Acids and Exhibits Fatty Acyl-CoA-stimulated…

TLDR
Consistent with its exhibiting a function in yeast akin to that in the plant, CTS rescued the oleate growth phenotype of the pxa1 pxa2Δ mutant, and restored β-oxidation of fatty acids with a range of chain lengths and varying degrees of desaturation.
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