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A comparison of the molecular species compositions of mammalian lung surfactant phospholipids.
- A. Postle, Emma Heeley, D. Wilton
- Chemistry, Medicine
- Comparative biochemistry and physiology. Part A…
- 1 May 2001
While dipalmitoyl phosphatidylcholine (PC16:0/16:0) is essential for pulmonary surfactant function, roles for other individual molecular species of surfactant phospholipids have not been established.… Expand
The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin.
The binding of lysophospholipids to rat liver fatty acid-binding protein (FABP) and to BSA and human serum albumin was investigated by using competitive displacement fluorescence assays by monitoring… Expand
Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan.
Secreted phospholipases A(2) have similar catalytic sites, but vastly different interfacial binding surfaces that modulate their binding affinity for different kinds of phospholipid vesicles by… Expand
Potentiation of Tumor Necrosis Factor α-induced Secreted Phospholipase A2 (sPLA2)-IIA Expression in Mesangial Cells by an Autocrine Loop Involving sPLA2 and Peroxisome Proliferator-activated Receptor…
- S. Beck, G. Lambeau, +6 authors M. Kaszkin
- Biology, Medicine
- Journal of Biological Chemistry
- 8 August 2003
In rat mesangial cells, exogenously added secreted phospholipases A2 (sPLA2s) potentiate the expression of pro-inflammatory sPLA2-IIA first induced by cytokines like tumor necrosis factor-α (TNFα)… Expand
Catalytic and non-catalytic functions of human IIA phospholipase A2.
Group IIA phospholipase A2 (PLA2) is a low-molecular-mass secreted PLA2 enzyme that has been identified as an acute phase protein with a role in the inflammatory response to infection and trauma. The… Expand
The organisation of cholesterol and ergosterol in lipid bilayers based on studies using non-perturbing fluorescent sterol probes.
The fluorescence properties of dehydroergosterol and cholesta-5,7,9-trien-3 beta-ol have been studied in organic solution, in aqueous dispersions and incorporated into aqueous lipid dispersions. The… Expand
Binding of recombinant rat liver fatty acid-binding protein to small anionic phospholipid vesicles results in ligand release: a model for interfacial binding and fatty acid targeting.
A number of intracellular proteins bind to negatively charged phospholipid membranes, and this interfacial binding results in a conformational change that modulates the activity of the protein. Using… Expand
Anionic phospholipids, interfacial binding and the regulation of cell functions.
Effect on ligand binding of arginine mutations in recombinant rat liver fatty acid-binding protein.
Rat liver fatty acid-binding protein is able to accommodate a wide range of non-polar anions in addition to long-chain fatty acids. The two arginine residues of rat liver fatty acid-binding protein,… Expand
Monoacylglycerol binding to human serum albumin: evidence that monooleoylglycerol binds at the dansylsarcosine site.
The binding of monoacylglycerides of long-chain fatty acids to human serum albumin has been examined using monooleoylglycerol as the ligand. Binding was investigated using changes in tryptophan… Expand