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spindle assembly

Known as: bipolar spindle formation, bipolar spindle biosynthesis, spindle biosynthesis 
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that… 
National Institutes of Health

Related topics

Related topics

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Narrower (4)

mitotic spindle organization in nucleusspindle assembly involved in female meiosisspindle assembly involved in meiosisspindle midzone assembly
regulation of spindle assembly

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Mechanisms of Mitotic Spindle Assembly.
Life depends on cell proliferation and the accurate segregation of chromosomes, which are mediated by the microtubule (MT)-based… 
Highly Cited
2008
Highly Cited
2008
Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle
Since the discovery of γ-tubulin, attention has focused on its involvement as a microtubule nucleator at the centrosome. However… 
Highly Cited
2006
Highly Cited
2006
Phosphoproteome analysis of the human mitotic spindle.
During cell division, the mitotic spindle segregates the sister chromatids into two nascent cells, such that each daughter cell… 
Highly Cited
2005
Highly Cited
2005
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks
During cell division, mitotic spindles are assembled by microtubule-based motor proteins. The bipolar organization of spindles is… 
Highly Cited
2002
Highly Cited
2002
Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
In Xenopus laevis egg extracts, TPX2 is required for the Ran-GTP-dependent assembly of microtubules around chromosomes. Here we… 
Highly Cited
2001
Highly Cited
2001
Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.
The small GTPase Ran, bound to GTP, is required for the induction of spindle formation by chromosomes in M phase. High… 
Highly Cited
2001
Highly Cited
2001
Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.
The GTPase Ran has recently been shown to stimulate microtubule polymerization in mitotic extracts, but its mode of action is not… 
Highly Cited
2000
Highly Cited
2000
Establishing Biorientation Occurs with Precocious Separation of the Sister Kinetochores, but Not the Arms, in the Early Spindle of Budding Yeast
Highly Cited
1992
Highly Cited
1992
Meiotic spindle assembly in Drosophila females: behavior of nonexchange chromosomes and the effects of mutations in the nod kinesin-like protein
Mature Drosophila oocytes are arrested in metaphase of the first meiotic division. We have examined microtubule and chromatin… 
Highly Cited
1987
Highly Cited
1987
DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe
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