spindle assembly

Known as: bipolar spindle formation, bipolar spindle biosynthesis, spindle biosynthesis 
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1952-2017
05010019522016

Papers overview

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Highly Cited
2009
Highly Cited
2009
The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when… (More)
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Highly Cited
2003
Highly Cited
2003
The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle… (More)
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Highly Cited
2003
Highly Cited
2003
The serine-threonine kinase gene AURORA-A is commonly amplified in epithelial malignancies. Here we show that elevated Aurora-A… (More)
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Highly Cited
2000
Highly Cited
2000
Monastrol, a cell-permeable small molecule inhibitor of the mitotic kinesin, Eg5, arrests cells in mitosis with monoastral… (More)
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Highly Cited
1999
Highly Cited
1999
Ran is an abundant nuclear GTPase with a clear role in nuclear transport during interphase but with roles in mitotic regulation… (More)
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Highly Cited
1996
Highly Cited
1996
The spindle assembly checkpoint delays anaphase until all chromosomes are attached to a mitotic spindle. The mad (mitotic arrest… (More)
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Highly Cited
1996
Highly Cited
1996
NuMA is a nuclear protein during interphase but redistributes to the spindle poles early in mitosis. To investigate its role… (More)
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Highly Cited
1996
Highly Cited
1996
We isolated a cDNA clone encoding a kinesin-related protein, which we named XKCM1. Antibodies to XKCM1 stain mitotic centromeres… (More)
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Highly Cited
1995
Highly Cited
1995
We have isolated a human homolog of Xenopus Eg5, a kinesin-related motor protein implicated in the assembly and dynamics of the… (More)
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Highly Cited
1991
Highly Cited
1991
We have used Xenopus egg extracts to study spindle morphogenesis in a cell-free system and have identified two pathways of… (More)
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