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spindle assembly

Known as: bipolar spindle formation, bipolar spindle biosynthesis, spindle biosynthesis 
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that… 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (4)

mitotic spindle organization in nucleusspindle assembly involved in female meiosisspindle assembly involved in meiosisspindle midzone assembly
regulation of spindle assembly

Papers overview

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Highly Cited
2009
Highly Cited
2009
A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies
Objectives: Polo-like kinase1 (PLK1) belongs to the family of serine/threonine kinases and plays an important role in centrosome… 
Highly Cited
2008
Highly Cited
2008
CDC25A phosphatase controls meiosis I progression in mouse oocytes.
Highly Cited
2005
Highly Cited
2005
Docking and Rolling, a Model of How the Mitotic Motor Eg5 Works*
Whereas kinesin I is designed to transport cargoes long distances in isolation, a closely related kinesin motor, Eg5, is designed… 
Highly Cited
2005
Highly Cited
2005
SRC tyrosine kinase and multidrug resistance protein-1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells.
Src tyrosine kinase has been found to be overexpressed in both mouse and human ovarian cancer cells as well as in human primary… 
Highly Cited
2001
Highly Cited
2001
Vanadocenes as potent anti-proliferative agents disrupting mitotic spindle formation in cancer cells
We present experimental data which establish the organometallic compounds vanadocene dichloride (VDC) and vanadocene… 
Highly Cited
1999
Highly Cited
1999
Effects of cooling germinal vesicle–stage bovine oocytes on meiotic spindle formation following in vitro maturation
Attempts to cryopreserve bovine oocytes result in low survival because of their sensitivity to temperatures near 0°C. This study… 
Highly Cited
1996
Highly Cited
1996
Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28
In eukaryotes, mitosis requires the activation of cdc2 kinase via association with cyclin B and dephosphorylation of the… 
Review
1995
Review
1995
Meiosis in Drosophila: seeing is believing.
Recently many exciting advances have been achieved in our understanding of Drosophila meiosis due to combined cytological and… 
Highly Cited
1992
Highly Cited
1992
Effect of donor cell cycle stage on chromatin and spindle morphology in nuclear transplant rabbit embryos.
We investigated the influence of the cell cycle stage of the nuclear donor on prematurely condensed chromatin (PCC) and spindle… 
Highly Cited
1977
Highly Cited
1977
Specific changes in the pattern of protein synthesis during meiotic maturation of mammalian oocytes in vitro.
High resolution two-dimensional electrophoresis has been used to examine the pattern of protein synthesis during meiotic… 
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