sphingosine 1-phosphate

Known as: (2-Amino-3-Hydroxy-Octadec-4-Enoxy)Phosphonic Acid, (2S,3R,4E)-2-Amino-3-Hydroxyoctadec-4-En-1-Yl Dihydrogen Phosphate, Sphing-4-Enine 1-Phosphate 
A bioactive sphingolipid comprised of a sphingosine with a phosphate group attached to the carbon at position 1. Sphingosine 1-phosphate (S1P) binds… (More)

Topic mentions per year

Topic mentions per year

1968-2017
020040019682017

Papers overview

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Highly Cited
2009
Highly Cited
2009
The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) can act intracellularly independently of its cell surface receptors… (More)
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Highly Cited
2007
Highly Cited
2007
Lymphocytes require sphingosine-1-phosphate (S1P) receptor-1 to exit lymphoid organs, but the source(s) of extracellular S1P and… (More)
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Highly Cited
2005
Highly Cited
2005
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cell and tissue responses via a set of cell… (More)
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Highly Cited
2004
Highly Cited
2004
FTY720 is an immunosuppressant that reduces circulating levels of naïve lymphocytes by increasing their localization and… (More)
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Highly Cited
2002
Highly Cited
2002
Blood lymphocyte numbers, essential for the development of efficient immune responses, are maintained by recirculation through… (More)
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Highly Cited
2002
Highly Cited
2002
Immunosuppressant drugs such as cyclosporin have allowed widespread organ transplantation, but their utility remains limited by… (More)
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Highly Cited
2001
Highly Cited
2001
Substances released by platelets during blood clotting are essential participants in events that link hemostasis and angiogenesis… (More)
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Highly Cited
2000
Highly Cited
2000
Sphingolipid signaling pathways have been implicated in many critical cellular events. Sphingosine-1-phosphate (SPP), a… (More)
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Highly Cited
1999
Highly Cited
1999
Vascular endothelial cells undergo morphogenesis into capillary networks in response to angiogenic factors. We show here that… (More)
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Highly Cited
1996
Highly Cited
1996
Ceramide is an important regulatory participant of programmed cell death (apoptosis) induced by tumour-necrosis factor (TNF… (More)
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