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sphingosine 1-phosphate

Known as: (2-Amino-3-Hydroxy-Octadec-4-Enoxy)Phosphonic Acid, (2S,3R,4E)-2-Amino-3-Hydroxyoctadec-4-En-1-Yl Dihydrogen Phosphate, Sphing-4-Enine 1-Phosphate 
A bioactive sphingolipid comprised of a sphingosine with a phosphate group attached to the carbon at position 1. Sphingosine 1-phosphate (S1P) binds… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

LysophospholipidsSphingosine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement.
Activated protein C (APC) has both anticoagulant activity and direct cell-signaling properties. APC has been reported to promote… 
Review
2008
Review
2008
The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction?
Highly Cited
2006
Highly Cited
2006
Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor.
Highly Cited
2005
Highly Cited
2005
Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/jlr.M500268-JLR200
The bioactive molecule sphingosine 1-phosphate (S1P) is abundantly stored in platelets and can be released extracellularly… 
Highly Cited
2005
Highly Cited
2005
Products by the sphingosine kinase/sphingosine 1‐phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis
Sphingosine 1‐phosphate (S1P) functions as a ligand for the S1P/EDG family receptors. For years, intracellular signaling roles… 
Highly Cited
2003
Highly Cited
2003
Sphingosine 1-Phosphate and Platelet-derived Growth Factor (PDGF) Act via PDGFβ Receptor-Sphingosine 1-Phosphate Receptor Complexes in Airway Smooth Muscle Cells*
Platelet-derived growth factor (PDGF) and sphingosine 1-phosphate (S1P) act via PDGFβ receptor-S1P1 receptor complexes in airway… 
Review
2003
Review
2003
The roles of ceramide and complex sphingolipids in neuronal cell function.
Review
2003
Review
2003
Sphingosine-1-phosphate signaling in endothelial activation.
The signaling and functions of the Endothelial Differentiation Gene (EDG) family of G protein-coupled receptors have been… 
Review
1999
Review
1999
Life on the edg.
Highly Cited
1997
Highly Cited
1997
Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors
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