sphingomyelin synthase activity

Known as: SMS2, phosphatidylcholine:ceramide cholinephosphotransferase activity, SM synthase activity 
Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. [EC:2.7.8.27, RHEA:18768]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2018
024619912018

Papers overview

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2008
2008
SMS [SM (sphingomyelin) synthase] is a class of enzymes that produces SM by transferring a phosphocholine moiety on to ceramide… (More)
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2008
2008
We have shown that overexpression of SMS1, an enzyme that converts de novo ceramide into sphingomyelin, is accompanied by… (More)
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2007
2007
Sphingomyelin plays a very important role both in cell membrane formation that may well have an impact on the development of… (More)
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Highly Cited
2004
Highly Cited
2004
Sphingomyelin (SM) synthase has been assumed to be involved in both cell death and survival by regulating pro-apoptotic mediator… (More)
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2003
2003
Sphingomyelin synthase is the enzyme that synthesizes sphingomyelin (SM) in mammalian cells by transferring a phosphorylcholine… (More)
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2001
2001
We recently reported that the marked decrease in cellular ceramide in primary astrocytes is an early event associated with the… (More)
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1998
1998
The role, origin, and mode of action of the lipid messenger ceramide in programmed cell death and its linkage to receptor… (More)
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1994
1994
This work describes two unusual features of membrane development in a eukaryotic cell. (a) The induction of an extensive network… (More)
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1993
1993
The purpose of this work was to determine whether alterations in the lipid composition of rat liver microsomal membranes existed… (More)
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Highly Cited
1992
Highly Cited
1992
In our attempt to assess the topology of glucosylceramide biosynthesis, we have employed a truncated ceramide analogue that… (More)
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