FAQ

sphingomyelin synthase activity

Known as: SMS2, phosphatidylcholine:ceramide cholinephosphotransferase activity, SM synthase activity 
Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. [EC:2.7.8.27, RHEA:18768]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2018
024619912018

Related topics

Related topics

2 relations
SGMS1 wt Allele

Broader (1)

SGMS2 wt Allele

Related mentions per year

Related mentions per year

1980-2018
19801990200020102020
sphingomyelin synthase activity
SGMS1 wt Allele
SGMS2 wt Allele

Papers overview

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2008
2008
Sphingomyelin synthases regulate production of diacylglycerol at the Golgi.
SMS [SM (sphingomyelin) synthase] is a class of enzymes that produces SM by transferring a phosphocholine moiety on to ceramide… (More)
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2008
2008
Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage.
We have shown that overexpression of SMS1, an enzyme that converts de novo ceramide into sphingomyelin, is accompanied by… (More)
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2007
2007
Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.
Sphingomyelin plays a very important role both in cell membrane formation that may well have an impact on the development of… (More)
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Highly Cited
2004
Highly Cited
2004
Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.
Sphingomyelin (SM) synthase has been assumed to be involved in both cell death and survival by regulating pro-apoptotic mediator… (More)
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2003
2003
Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme.
Sphingomyelin synthase is the enzyme that synthesizes sphingomyelin (SM) in mammalian cells by transferring a phosphorylcholine… (More)
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2001
2001
Basic fibroblast growth factor-induced proliferation of primary astrocytes. evidence for the involvement of sphingomyelin biosynthesis.
We recently reported that the marked decrease in cellular ceramide in primary astrocytes is an early event associated with the… (More)
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1998
1998
Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthases by caspases in apoptotic Kym-1 cells.
The role, origin, and mode of action of the lipid messenger ceramide in programmed cell death and its linkage to receptor… (More)
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1994
1994
Plasmodium falciparum exports the Golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes.
This work describes two unusual features of membrane development in a eukaryotic cell. (a) The induction of an extensive network… (More)
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1993
1993
Microsomal sphingomyelin accumulation in thioacetamide-injured regenerating rat liver: involvement of sphingomyelin synthase activity.
The purpose of this work was to determine whether alterations in the lipid composition of rat liver microsomal membranes existed… (More)
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Highly Cited
1992
Highly Cited
1992
Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions
In our attempt to assess the topology of glucosylceramide biosynthesis, we have employed a truncated ceramide analogue that… (More)
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