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sphingomyelin synthase activity

Known as: SMS2, phosphatidylcholine:ceramide cholinephosphotransferase activity, SM synthase activity 
Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. [EC:2.7.8.27, RHEA:18768]
National Institutes of Health

Related topics

Related topics

1 relation
SGMS1 wt Allele

Papers overview

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2015
2015
PC-PLC/sphingomyelin synthase activity plays a central role in the development of myogenic tone in murine resistance arteries.
Myogenic tone is an intrinsic property of the vasculature that contributes to blood pressure control and tissue perfusion… Expand
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2014
2014
Hybrid SWOT Approach for Strategic Planning and Formulation in China Worldwide Express Mail Service
The traditional SWOT tool, which lists the S, W, O, T factors and groups them together to form some strategies, isconvenient for… Expand
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Highly Cited
2012
Highly Cited
2012
Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice.
OBJECTIVE Sphingomyelin synthase (SMS) catalyzes the conversion of ceramide to sphingomyelin and sits at the crossroads of… Expand
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2011
2011
Sphingomyelin Synthases Regulate Protein Trafficking and Secretion
Sphingomyelin synthases (SMS1 and 2) represent a class of enzymes that transfer a phosphocholine moiety from phosphatidylcholine… Expand
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2011
2011
Sphingomyelin synthase overexpression increases cholesterol accumulation and decreases cholesterol secretion in liver cells
BackgroundStudies have shown that plasma high density lipoprotein cholesterol levels are negatively correlated with the… Expand
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2011
2011
Subcellular Targeting Domains of Sphingomyelin Synthase 1 and 2
Sphingomyelin synthase (SMS) sits at the crossroads of sphingomyelin (SM), ceramide, diacylglycerol (DAG) metabolism. It utilizes… Expand
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Highly Cited
2008
Highly Cited
2008
Sphingomyelin synthases regulate production of diacylglycerol at the Golgi.
SMS [SM (sphingomyelin) synthase] is a class of enzymes that produces SM by transferring a phosphocholine moiety on to ceramide… Expand
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2008
2008
Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage.
We have shown that overexpression of SMS1, an enzyme that converts de novo ceramide into sphingomyelin, is accompanied by… Expand
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Highly Cited
2007
Highly Cited
2007
Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells*
Sphingomyelin (SM) is a vital component of cellular membranes in organisms ranging from mammals to protozoa. Its production… Expand
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Highly Cited
2007
Highly Cited
2007
Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.
Sphingomyelin plays a very important role both in cell membrane formation that may well have an impact on the development of… Expand
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