Strategies for overcoming p-glycoprotein-mediated drug resistance in acute myeloblastic leukaemia

@article{Pallis2004StrategiesFO,
  title={Strategies for overcoming p-glycoprotein-mediated drug resistance in acute myeloblastic leukaemia},
  author={Monica Pallis and N. H. Russell},
  journal={Leukemia},
  year={2004},
  volume={18},
  pages={1927-1930}
}
P-glycoprotein (pgp), the product of the MDR1 gene, is a 170 kDa ATP-binding cassette (ABC) membrane transporter. (The gene is now also known as ABCB1 in the ABC transporter nomenclature.) Normally expressed in the intestine, blood–brain barrier, kidney, liver, testes, placenta and in healthy haematopoietic stem cells, pgp is also expressed by approximately 35% of AML cases under 60 years of age and approximately 70% of elderly patients. It is rarely expressed in children. Numerous studies have… CONTINUE READING
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