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sphingomyelin biosynthetic process

Known as: sphingomyelin synthesis, sphingomyelin formation, sphingomyelin anabolism 
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]
National Institutes of Health

Papers overview

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2012
2012
Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis
Oxysterol-binding protein (OSBP) is involved in endoplasmic reticulum (ER)-Golgi sterol transport, but how its activity is… Expand
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2010
2010
High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei
Obesity increases the risk for hepatic steatosis. Recent studies have demonstrated that high fat diet (HFD) may affect… Expand
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2010
2010
Cog2 Null Mutant CHO Cells Show Defective Sphingomyelin Synthesis*
The COG (conserved oligomeric Golgi complex) is a Golgi-associated tethering complex involved in retrograde trafficking of… Expand
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2008
2008
SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.
ABCA1 transport of cholesterol and phospholipids to nascent HDL particles plays a central role in lipoprotein metabolism and… Expand
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2006
2006
Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.
Plasma sphingomyelin (SM) has been suggested as a risk factor for coronary heart disease independent of cholesterol levels. A… Expand
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Highly Cited
2004
Highly Cited
2004
Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice.
BACKGROUND In clinical studies, sphingomyelin (SM) plasma levels correlated with the occurrence of coronary heart disease… Expand
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1998
1998
Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25…
Sphingomyelin (SM) and cholesterol content is positively correlated in cellular membranes, and in several pathological and… Expand
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1998
1998
The rate of sphingomyelin synthesis de novo is influenced by the level of cholesterol in cultured human skin fibroblasts.
Plasma membrane sphingomyelin (SM) is known to affect the cellular distribution of cholesterol. The aim of this work was to… Expand
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1995
1995
25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change… Expand
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Review
1990
Review
1990
An update of the enzymology and regulation of sphingomyelin metabolism.
Sphingomyelin is found in plasma membranes and related organelles (such as endocytic vesicles and lysosomes) of all tissues, as… Expand
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