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sphingomyelin biosynthetic process

Known as: sphingomyelin synthesis, sphingomyelin formation, sphingomyelin anabolism 
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis
Oxysterol-binding protein (OSBP) is involved in endoplasmic reticulum (ER)-Golgi sterol transport, but how its activity is… Expand
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Highly Cited
2006
Highly Cited
2006
Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.
Plasma sphingomyelin (SM) has been suggested as a risk factor for coronary heart disease independent of cholesterol levels. A… Expand
Highly Cited
2004
Highly Cited
2004
Inhibition of Sphingomyelin Synthesis Reduces Atherogenesis in Apolipoprotein E–Knockout Mice
Background—In clinical studies, sphingomyelin (SM) plasma levels correlated with the occurrence of coronary heart disease… Expand
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Highly Cited
2001
Highly Cited
2001
Basic Fibroblast Growth Factor-induced Proliferation of Primary Astrocytes
We recently reported that the marked decrease in cellular ceramide in primary astrocytes is an early event associated with the… Expand
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Highly Cited
1998
Highly Cited
1998
Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25…
Sphingomyelin (SM) and cholesterol content is positively correlated in cellular membranes, and in several pathological and… Expand
1998
1998
The rate of sphingomyelin synthesis de novo is influenced by the level of cholesterol in cultured human skin fibroblasts.
Plasma membrane sphingomyelin (SM) is known to affect the cellular distribution of cholesterol. The aim of this work was to… Expand
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Highly Cited
1995
Highly Cited
1995
25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.
  • N. Ridgway
  • Journal of lipid research
  • 1995
    • Corpus ID: 31864119
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change… Expand
1992
1992
Stimulation of sphingomyelin biosynthesis by brefeldin A and sphingomyelin breakdown by okadaic acid treatment of rat hepatocytes.
Studies on sphingomyelin metabolism in rat hepatocytes were facilitated by the use of choline-deficient cells which allowed for… Expand
Review
1990
Review
1990
An update of the enzymology and regulation of sphingomyelin metabolism.
Sphingomyelin is found in plasma membranes and related organelles (such as endocytic vesicles and lysosomes) of all tissues, as… Expand
1980
1980
Glucocorticoid effects on lipid metabolism in HeLa cells: inhibition of cholesterol synthesis and increased sphingomyelin synthesis.
Glucocorticoid treatment had a variety of effects on lipid composition of HeLa S3G (HeLa 65) cells. Total cellular cholesterol… Expand
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