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sphingomyelin biosynthetic process

Known as: sphingomyelin synthesis, sphingomyelin formation, sphingomyelin anabolism 
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis
Oxysterol-binding protein (OSBP) is involved in endoplasmic reticulum (ER)-Golgi sterol transport, but how its activity is… 
Highly Cited
2010
Highly Cited
2010
High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei
Obesity increases the risk for hepatic steatosis. Recent studies have demonstrated that high fat diet (HFD) may affect… 
Highly Cited
2006
Highly Cited
2006
Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.
Highly Cited
2004
Highly Cited
2004
Inhibition of Sphingomyelin Synthesis Reduces Atherogenesis in Apolipoprotein E–Knockout Mice
Background—In clinical studies, sphingomyelin (SM) plasma levels correlated with the occurrence of coronary heart disease… 
Highly Cited
2001
Highly Cited
2001
Basic Fibroblast Growth Factor-induced Proliferation of Primary Astrocytes
We recently reported that the marked decrease in cellular ceramide in primary astrocytes is an early event associated with the… 
Highly Cited
2000
Highly Cited
2000
Reconstitution of ATP- and Cytosol-dependent Transport of de Novo Synthesized Ceramide to the Site of Sphingomyelin Synthesis in Semi-intact Cells*
Transport of ceramide synthesized at the endoplasmic reticulum to the Golgi compartment, where sphingomyelin (SM) synthase exists… 
Highly Cited
1998
Highly Cited
1998
Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25…
Sphingomyelin (SM) and cholesterol content is positively correlated in cellular membranes, and in several pathological and… 
1998
1998
The rate of sphingomyelin synthesis de novo is influenced by the level of cholesterol in cultured human skin fibroblasts.
Plasma membrane sphingomyelin (SM) is known to affect the cellular distribution of cholesterol. The aim of this work was to… 
Highly Cited
1995
Highly Cited
1995
25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.
  • N. Ridgway
  • Journal of lipid research
  • 1995
  • Corpus ID: 31864119
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change… 
Review
1990
Review
1990
An update of the enzymology and regulation of sphingomyelin metabolism.
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