FAQ

sphingomyelin biosynthetic process

Known as: sphingomyelin synthesis, sphingomyelin formation, sphingomyelin anabolism 
The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine. [ISBN:0198506732]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2016
02419772016

Papers overview

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2010
2010
High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei
Obesity increases the risk for hepatic steatosis. Recent studies have demonstrated that high fat diet (HFD) may affect… (More)
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2010
2010
Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death
Ceramide can be converted into sphingomyelin by sphingomyelin synthases (SMS) 1 and 2. In this study, we show that in human… (More)
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2008
2008
OSBP negatively regulates ABCA1 protein stability.
Oxysterol binding to liver X receptors (LXR) increases the transcription of genes involved in cholesterol efflux and disposal… (More)
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2006
2006
Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice.
Plasma sphingomyelin (SM) has been suggested as a risk factor for coronary heart disease independent of cholesterol levels. A… (More)
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Highly Cited
2004
Highly Cited
2004
Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice.
BACKGROUND In clinical studies, sphingomyelin (SM) plasma levels correlated with the occurrence of coronary heart disease… (More)
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2001
2001
Basic fibroblast growth factor-induced proliferation of primary astrocytes. evidence for the involvement of sphingomyelin biosynthesis.
We recently reported that the marked decrease in cellular ceramide in primary astrocytes is an early event associated with the… (More)
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2001
2001
A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis.
Ceramide produced at the endoplasmic reticulum (ER) is transported to the lumen of the Golgi apparatus for conversion to… (More)
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2000
2000
Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta…
We examined the effects of reduction of sphingomyelin level on cholesterol behavior in cells using 2 types of Chinese hamster… (More)
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1998
1998
Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine…
Lysenin, a hemolytic protein derived from the earthworm Eisenia foetida, has a high affinity for sphingomyelin. Chinese hamster… (More)
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1995
1995
25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change… (More)
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