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siltuximab

Known as: Anti-IL-6 Chimeric Monoclonal Antibody 
A chimeric, human-murine, monoclonal antibody targeting the pro-inflammatory cytokine interleukin 6 (IL-6), with antitumor and anti-inflammatory… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (2)

Antineoplastic AgentsMonoclonal Antibodies
NCIt Antineoplastic Agent Terminologyantigen bindingsiltuximab 100 MG Injection [Sylvant]

Narrower (2)

cClB8 monoclonal antibodymonoclonal antibody CNTO 328

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Facilitatory Effect of IL-6 Deficiency on Long-Term Spatial Memory in Young Adult Mice
The significance of interleukin 6 (IL-6) in long-term reference memory was tested in the Morris water maze (MWM) in 4-month-old… 
Review
2016
Review
2016
Emerging antibodies for the treatment of multiple myeloma
ABSTRACT Introduction: Monoclonal antibodies mark the beginning of a new era in the context of multiple myeloma (MM) treatment… 
Review
2015
Review
2015
CONSUMPTION OF CHERRIES AS A STRATEGY TO ATTENUATE EXERCISE-INDUCED MUSCLE DAMAGE AND INFLAMMATION IN HUMANS.
BACKGROUND exercise-induced muscle damage (EIMD) is a multifactorial phenomenon that induces muscle function loss because of… 
2015
2015
Role of interleukin-6 gene polymorphisms in the development of prostate cancer.
We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development… 
2013
2013
CCN1 expression in interleukin-6 deficient mouse kidney in experimental model of heart failure.
Chronic heart failure often leads to worsening of the renal function. Mediators of this process include inflammatory and… 
2011
2011
Interleukin‐6 modifies mRNA expression in mouse skeletal muscle
Aim:  The aim of this study was to test the hypothesis that interleukin (IL)‐6 plays a role in exercise‐induced peroxisome… 
2009
2009
Comparison of renal dysfunction in wild-type, IL-6 KO and iNOS KO mice hind limb tourniquet-reperfusion model.
2004
2004
Evaluation of effluent markers cancer antigen 125, vascular endothelial growth factor, and interleukin-6: relationship with peritoneal transport.
Peritoneal hyperpermeability has been associated with increased levels of effluent vascular endothelial growth factor (VEGF) and… 
1996
1996
In vivo role of IL-6 on the viral load and on immunological abnormalities of HIV-infected patients.
In vitro experiments have suggested that interleukin (IL)-6 may contribute to human immunodeficiency virus (HIV) burden and to… 
Highly Cited
1993
Highly Cited
1993
Antibodies chaperone circulating IL-6. Paradoxical effects of anti-IL-6 "neutralizing" antibodies in vivo.
In the baboon or the mouse, a stimulus such as LPS, TNF, or IL-1 typically led to a rapid induction of circulating IL-6, the… 
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