siltuximab

Known as: Anti-IL-6 Chimeric Monoclonal Antibody 
A chimeric, human-murine, monoclonal antibody targeting the pro-inflammatory cytokine interleukin 6 (IL-6), with antitumor and anti-inflammatory… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Multicentric Castleman's disease is a rare lymphoproliferative disorder driven by dysregulated production of… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE To evaluate the safety and pharmacokinetics of siltuximab, an anti-interleukin-6 chimeric monoclonal antibody (mAb) in… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE We investigated whether inhibition of interleukin 6 (IL-6) has therapeutic activity in ovarian cancer via abrogation of a… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Interleukin-6 (IL-6) has emerged as a key factor in the pathogenesis of the atypical lymphoproliferative disorder… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Interleukin-6 (IL-6) facilitates cancer cell survival via pleotrophic effects. We conducted a multicenter phase II study… (More)
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Highly Cited
2010
Highly Cited
2010
Background:Serum interleukin (IL)-6 levels correlate with disease outcomes in renal cell carcinoma (RCC) patients. Siltuximab, a… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE We investigated the in vitro and in vivo anti-multiple myeloma activity of monoclonal antibody (mAb) 1339, a high… (More)
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Review
2008
Review
2008
Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates immune responses and inflammatory reactions. Overproduction of IL-6… (More)
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Highly Cited
1997
Highly Cited
1997
Interleukin-6 (IL-6), among other cytokines, is thought to be involved in the regulation of sickness behavior (e.g., anorexia… (More)
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Highly Cited
1994
Highly Cited
1994
The role of interleukin 6 (IL-6) in the toxic sequelae of sepsis is controversial. To assess the part of IL-6 in inflammatory… (More)
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