senescence-associated heterochromatin focus

Known as: SAHF, senescence-associated heterochromatin foci 
A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched… (More)
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Two major mechanisms have been causally implicated in the establishment of cellular senescence: the activation of the DNA damage… (More)
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Highly Cited
2011
Highly Cited
2011
Cellular senescence, an irreversible proliferation arrest evoked by stresses such as oncogene activation, telomere dysfunction… (More)
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Review
2011
Review
2011
Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-suppressive mechanism. However, due to… (More)
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Highly Cited
2007
Highly Cited
2007
Senescence is characterized by an irreversible cell proliferation arrest. Specialized domains of facultative heterochromatin… (More)
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Highly Cited
2007
Highly Cited
2007
Cellular senescence is an irreversible proliferation arrest triggered by short chromosome telomeres, activated oncogenes, and… (More)
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Highly Cited
2006
Highly Cited
2006
Cellular senescence is a tumor-suppressing mechanism that is accompanied by characteristic chromatin condensation called… (More)
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Highly Cited
2005
Highly Cited
2005
Adenovirus E1A-associated p400 belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Here, we report that p400 is a… (More)
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Highly Cited
2005
Highly Cited
2005
In senescent cells, specialized domains of transcriptionally silent senescence-associated heterochromatic foci (SAHF), containing… (More)
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Highly Cited
2005
Highly Cited
2005
The INK4a and ARF genes found at the CDKN2A locus are key effectors of cellular senescence that is believed to act as a powerful… (More)
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Highly Cited
2003
Highly Cited
2003
Cellular senescence is an extremely stable form of cell cycle arrest that limits the proliferation of damaged cells and may act… (More)
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