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senescence-associated heterochromatin focus

Known as: SAHF, senescence-associated heterochromatin foci 
A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched… 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress
Abstract Although oxidative stress has been shown to induce senescence and replication stress independently, no study has… 
2016
2016
miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways.
Highly Cited
2015
Highly Cited
2015
Wnt5A promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy… 
Highly Cited
2011
Highly Cited
2011
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a
Cellular senescence, an irreversible proliferation arrest evoked by stresses such as oncogene activation, telomere dysfunction… 
Highly Cited
2010
Highly Cited
2010
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci
BackgroundCellular senescence is a permanent growth arrest that occurs in response to cellular stressors, such as telomere… 
Review
2009
Review
2009
A comparative analysis of the cell biology of senescence and aging
Various intracellular organelles, such as lysosomes, mitochondria, nuclei, and cytoskeletons, change during replicative… 
Highly Cited
2009
Highly Cited
2009
The transcription factor ZBP‐89 suppresses p16 expression through a histone modification mechanism to affect cell senescence
The transcription factor ZBP‐89 has been implicated in the induction of growth arrest and apoptosis. In this article, we… 
Review
2007
Review
2007
Heterochromatin and its Relationship to Cell Senescence and Cancer Therapy
Our goal is to understand the impact of chromatin structure on cell proliferation, cell and tissue aging, cancer and cancer… 
Highly Cited
2005
Highly Cited
2005
Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.
The INK4a and ARF genes found at the CDKN2A locus are key effectors of cellular senescence that is believed to act as a powerful… 
Highly Cited
2005
Highly Cited
2005
The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway.
Adenovirus E1A-associated p400 belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Here, we report that p400 is a… 
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