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Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
TLDR
Findings suggest a functional interaction between BRCA1 and Rad51 in the meiotic and mitotic cell cycles, which, in turn, suggests a role for BRC a1 in the control of recombination and of genome integrity.
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.
TLDR
PALB2 licenses key cellular biochemical properties of BRCA2 and ensures its tumor suppression function, as well as enabling homologous recombination (HR)-based, error-free DNA double-strand break repair (DSBR) and intra-S phase DNA damage checkpoint control.
Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage
TLDR
The data imply that the BRCA1 S phase foci are dynamic physiological elements, responsive to DNA damage, and that B RCA1-containing multiprotein complexes participate in a replication checkpoint response.
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing.
TLDR
The data suggest that Dicer participates in multiple, fundamental biological processes in a mammalian organism, ranging from stem cell differentiation to the maintenance of centromeric heterochromatin structure and Centromeric silencing.
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
TLDR
Observations indicate that TBK1 and NF-κB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer.
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.
TLDR
It is shown that p300 molecules lacking an intact E1A-binding site can bypass E 1A repression and restore to a significant extent the activity of the SV40 enhancer, even in the presence of high levels of E1a protein.
Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300
TLDR
Mouse development is exquisitely sensitive to the overall gene dosage of p300 and cbp, providing genetic evidence that a coactivator endowed with histone acetyltransferase activity is essential for mammalian cell proliferation and development.
A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells
TLDR
To better elucidate the molecular mechanism of repression by E2F-6, the factor is purified from cultured cells and chromatin modifiers such as a novel histone methyltransferase that modifies lysine 9 of histone H3, HP1γ, and Polycomb group (PcG) proteins are suggested to contribute to silencing of E1- and Myc-responsive genes in quiescent cells.
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
TLDR
All D-type cyclins do not function equivalently, and one of them plays a major role in reversing the cycle-blocking function of a known tumor suppressor.
BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function
TLDR
A BACH1 derivative, bearing a mutation in a residue that was essential for catalytic function in other helicases, interfered with normal double-strand break repair in a manner that was dependent on its BRCA1 binding function.
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