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senazole

Known as: sanazole, technetium-99m-cyclam AK 2123 
 
National Institutes of Health

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AK 2123

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2018
2018
Tumor control by hypoxia‐specific chemotargeting of iron‐oxide nanoparticle – Berberine complexes in a mouse model
Aim: To evaluate the therapeutic efficacy of hypoxic cell‐sensitizer Sanazole (SAN) –directed targeting of cytotoxic drug… Expand
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2009
2009
Enhancement of radiation-induced apoptosis of human lymphoma U937 cells by sanazole
Sanazole has been tested clinically as a hypoxic cell radiosensitizer. In this study, we determined whether sanazole enhances the… Expand
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2009
2009
Enhancement of hyperthermia-induced apoptosis by sanazole in human lymphoma U937 cells
Sanazole has been tested clinically as a hypoxic cell radiosensitizer. The aim of the present study was to investigate whether… Expand
2005
2005
Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo.
Sanazole (AK-2123, 3-nitrotriazole derivative, N1-(3-methoxypropyl)-2-(3-nitro-1 H-1,2,4-triazol-1-yl)acetamide) and nimorazole… Expand
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2004
2004
Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxia.
The preparation of a polyazamacrocyclic-nitrotriazole conjugate for radiolabeling with the therapeutic radioisotope viz. (177)Lu… Expand
2004
2004
Production of nitric oxide by hypoxic radiosensitizer sanazole.
AIM In this work we investigated the ability of hypoxia-selective radiosensitizer--sanazole to produce nitric oxide (NO… Expand
2003
2003
Radiosensitizer Sanazole (AK-2123) enhances γ-radiation-induced Apoptosis in murine fibrosarcoma
Sanazole/AK-2123/γ-Radiation/DNA damage/Apoptosis/Radiosensitizer. Sanazole (AK-2123) (N-2′-methoxy ethyl)-2-(3″-nitro-1… Expand
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2001
2001
Effect of a hypoxic radiosensitizer, AK 2123 (Sanazole), on yeast Saccharomyces cerevisiae.
Sanazole/DNA repair/Hypoxic radiosensitization/DNA polymerases/Saccharomyces cerevisiae Yeast Saccharomyces cerevisiae can exist… Expand
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2000
2000
Redox reactions of sanazole (AK-2123) in aqueous solutions: a pulse radiolysis study.
The redox chemistry of sanazole, an efficient hypoxic cell radiosensitizer, generally referred to as AK-2123, was studied by… Expand
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2000
2000
Radiation induced effect of the vitamins C, E and beta-carotene on sanazole efficiency. A study in vitro.
The effect of the vitamins C, E-acetate and beta-carotene on the sanazole (AK-2123) efficiency was investigated in vitro (E. coli… Expand
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