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senazole

Known as: sanazole, technetium-99m-cyclam AK 2123 
 
National Institutes of Health

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AK 2123

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2018
2018
Tumor control by hypoxia‐specific chemotargeting of iron‐oxide nanoparticle – Berberine complexes in a mouse model
Aim: To evaluate the therapeutic efficacy of hypoxic cell‐sensitizer Sanazole (SAN) –directed targeting of cytotoxic drug… Expand
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2009
2009
Enhancement of radiation-induced apoptosis of human lymphoma U937 cells by sanazole
Sanazole has been tested clinically as a hypoxic cell radiosensitizer. In this study, we determined whether sanazole enhances the… Expand
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2009
2009
Enhancement of hyperthermia-induced apoptosis by sanazole in human lymphoma U937 cells
Sanazole has been tested clinically as a hypoxic cell radiosensitizer. The aim of the present study was to investigate whether… Expand
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2006
2006
Safety and radiosensitizing efficacy of sanazole (AK 2123) in oropharyngeal cancers: randomized controlled double blind clinical trial.
UNLABELLED Oropharynx is an important site of cancer in India. Global comparison indicates higher incidences in India… Expand
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2005
2005
Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo.
Sanazole (AK-2123, 3-nitrotriazole derivative, N1-(3-methoxypropyl)-2-(3-nitro-1 H-1,2,4-triazol-1-yl)acetamide) and nimorazole… Expand
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2004
2004
Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxia.
The preparation of a polyazamacrocyclic-nitrotriazole conjugate for radiolabeling with the therapeutic radioisotope viz. (177)Lu… Expand
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2003
2003
Radiosensitizer Sanazole (AK-2123) enhances γ-radiation-induced Apoptosis in murine fibrosarcoma
Sanazole/AK-2123/γ-Radiation/DNA damage/Apoptosis/Radiosensitizer. Sanazole (AK-2123) (N-2′-methoxy ethyl)-2-(3″-nitro-1… Expand
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2001
2001
Effect of a hypoxic radiosensitizer, AK 2123 (Sanazole), on yeast Saccharomyces cerevisiae.
Sanazole/DNA repair/Hypoxic radiosensitization/DNA polymerases/Saccharomyces cerevisiae Yeast Saccharomyces cerevisiae can exist… Expand
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2000
2000
Redox reactions of sanazole (AK-2123) in aqueous solutions: a pulse radiolysis study.
The redox chemistry of sanazole, an efficient hypoxic cell radiosensitizer, generally referred to as AK-2123, was studied by… Expand
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2000
2000
Radiation induced effect of the vitamins C, E and beta-carotene on sanazole efficiency. A study in vitro.
The effect of the vitamins C, E-acetate and beta-carotene on the sanazole (AK-2123) efficiency was investigated in vitro (E. coli… Expand
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