• Publications
  • Influence
Some novel approaches for radioprotection and the beneficial effect of natural products.
As India and many Eastern countries have an enormous heritage of vast natural dietary and time tested medicinal resources it is worth exploring the possibility of developing efficient, economically viable and clinically acceptable radioprotectors for human application from these resources. Expand
Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract.
  • J. Joy, C. Nair
  • Medicine
  • Journal of cancer research and therapeutics
  • 1 July 2008
Hydro-alcoholic extracts of Rubia cordifolia are effective in reducing the renal damage caused by the cancer chemotherapeutic drug cisplatin. Expand
Relevance of radioprotectors in radiotherapy: studies with tocopherol monoglucoside.
The results showed that the administration of TMG immediately after exposure to gamma-radiation can protect normal tissues against radiation damages in tumor-bearing mice and did not protect cancer cells from radiation damage. Expand
Protection of cellular DNA from γ-radiation-induced damages and enhancement in DNA repair by troxerutin
In addition to anti-erythrocytic, anti-thrombic, fibrinolytic and oedema-protective rheological activity, troxerutin offers protection against γ-radiation-induced micronuclei formation and DNA strand breaks and enhances repair of radiation-inducedDNA strand breaks. Expand
DNA protective properties of vanillin against gamma-radiation under different conditions: possible mechanisms.
Vanillin has ability to protect against DNA damage in plasmid pBR322, human and mouse peripheral blood leucocytes and splenic lymphocytes besides enhancing survival in splenicymphocytes against gamma-radiation, and that the possible mechanism may involve scavenging of radicals generated during radiation, apart from modulation of DNA repair. Expand
Radiation protection of DNA by ferulic acid under in vitro and in vivo conditions
There was a time-dependent disappearance of radiation induced strand breaks in blood leukocytes following whole body radiation exposure commensuration with DNA repair, suggesting enhanced DNA repair in ferulic acid treated animals. Expand
Prevention of cisplatin-induced nephrotoxicity by glucosides of ascorbic acid and alpha-tocopherol.
It is indicated that AsAG or TMG has a protective effect against cisplatin-induced renal damage in mice, mediated by preventing the decline of antioxidant status and having implications in use of AsAG in human application for protecting against drug-induced nephrotoxicity. Expand
Prevention of γ-radiation induced cellular genotoxicity by tempol: protection of hematopoietic system.
TPL enhanced the rate of repair of cellular DNA (blood leucocytes and bone marrow cells) damage when administered immediately after radiation exposure as revealed from the increased Cellular DNA Repair Index (CRI). Expand
Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo.
The findings suggest the potential use of Ganoderma polysaccharides as novel radioprotective agent and indicate the significant protective effect of Ganodma poly Saccharides against radiation induced damages. Expand
Effect of vinblastine sulfate on γ-radiation-induced DNA single-strand breaks in murine tissues
It appears that in addition to anticancer activity, vinblastine sulfate could offer protection to the normal tissues against gamma-radiation-induced DNA strand breaks. Expand