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securinine

Known as: (6S,11aR,11bS)-9,10,11,11a-Tetrahydro-8H-6,11b-methanofuro(2,3-c)pyrido(1,2-a)azepin-2(6H)-one, securinan-11-one 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (4)

AzepinesHeterocyclic Compounds, Bridged-RingLactonesPiperidines

Narrower (4)

allonorsecurinineallosecurininesecurinine methiodidesecurinine nitrate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease
Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the… 
2015
2015
Cytotoxic effects of stem bark extracts and pure compounds from Margaritaria discoidea on human ovarian cancer cell lines.
2009
2009
Enantioselective approach to Securinega alkaloids. Total synthesis of securinine and (-)-norsecurinine.
The most representative securinega alkaloids have been synthesized through a new strategy involving the palladium-catalyzed… 
2007
2007
Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists
Innate immune cell stimulation represents a complementary approach to vaccines and antimicrobial drugs to counter infectious… 
Highly Cited
2004
Highly Cited
2004
First diastereoselective chiral synthesis of (-)-securinine.
[reaction: see text] A diastereoselective total synthesis of securinine in optically pure form was achieved by employing ring… 
2004
2004
A new general access to either type of Securinega alkaloids: synthesis of securinine and (-)-allonorsecurinine.
The syntheses of securinine and (-)-allonorsecurinine have been achieved starting from easily available alpha-amino acid… 
Highly Cited
2001
Highly Cited
2001
An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.
[structure: see text]. The concise total synthesis of securinine in nine steps from readily available starting materials is… 
Highly Cited
1990
Highly Cited
1990
Antimalarial Compounds Containing an α, β-Unsaturated Carbonyl Moiety from Tanzanian Medicinal Plants1
Cyperus rotundus Zanthoxylum gilletii Margaritaria discoidea 1 N 2 3 C. rotundus 
Highly Cited
1990
Highly Cited
1990
Antibacterial activity of the leaves of Phyllanthus discoideus.
1984
1984
4-Methoxy-nor-Securinine, a New Alkaloid from Phyllanthus niruri
Phyllanthus niruri L 1 2 
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