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First diastereoselective chiral synthesis of (-)-securinine.
TLDR
A diastereoselective total synthesis of securinine in optically pure form was achieved by employing ring-closing metathesis of the corresponding dienyne compound as a key step. Expand
Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.
TLDR
This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the qu inazolinocarboline alkaloid rutaecarpine. Expand
Libraries of 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine derivatives via a multicomponent assembly process/1,3-dipolar cycloaddition strategy.
A Mannich-type multicomponent assembly process/1,3-dipolar cycloaddition strategy has been developed for the rapid and efficient construction of a parent tetrahydroisoquinoline fused isoxazolidineExpand
Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids.
A novel MCAP-cycloaddition sequence has been applied to the facile synthesis of β-carboline intermediates to gain rapid access to novel derivatives of yohimbine-like and corynanthe-like compoundsExpand
Multicomponent assembly processes for the synthesis of diverse yohimbine and corynanthe alkaloid analogues.
A strategy involving a Mannich-type multicomponent assembly process followed by a 1,3-dipolar cycloaddition has been developed for the rapid and efficient construction of parent heterocyclicExpand
Diastereoselective formal synthesis of a monoterpene alkaloid, (-)-incarvilline.
TLDR
Diastereoselective formal synthesis of a monoterpene alkaloid, (-)-incarvilline, was achieved by using an intramolecular Pauson-Khand reaction of (S)-N-[(E)-2-butenyl]-N-(3-butynyl-2-methoxymethoxy)-p-toluenesulfonamide as a key step. Expand
2-Aminobenzenesulfonamide-Containing Cyclononyne as Adjustable Click Reagent for Strain-Promoted Azide-Alkyne Cycloaddition.
TLDR
The synthesis of 2-aminobenzenesulfonamide-containing cyclononyne (ABSACN) is described for the development of an adjustable alkyne reagent in click reactions. Expand
Stereocontrolled synthesis of (+)-α-skytanthine by means of an intramolecular Pauson–Khand reaction
Abstract Diastereoselective synthesis of (+)-α-skytanthine was established by means of an intramolecular Pauson–Khand reaction ofExpand
Universal HPLC Detector for Hydrophilic Organic Compounds by Means of Total Organic Carbon Detection.
TLDR
A universal and analyte standard-free detector for aqueous-eluent-based high-performance liquid chromatography that can quantify many kinds of organic compounds with a single standard such as sodium bicarbonate is described. Expand
Facile synthesis of a benzindenoazepine alkaloid, bulgaramine, via samarium diiodide promoted ring expansion of an alpha-aminocarbonyl compound.
A novel synthetic path to a benzindenoazepine alkaloid was established by employing a samarium diiodide promoted ring expansion reaction of an alpha-aminocarbonyl compound as a key reaction, in whichExpand
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