saframycin R
National Institutes of Health
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Two series of novel hexacyclic skeletons and their thirty-four derivatives were prepared from l-tryptophan and l-DOPA. The…
Abstract A formal total synthesis of the antitumor marine natural product (rac)‐renieramycin T, which possesses a characteristic…
Saframycin A (SFM-A), a tetrahydroisoquinoline antibiotic isolated from Streptomyces lavendulae , shows potent anti-proliferation…
Saframycin A (SFM-A), a tetrahydroisoquinoline antibiotic isolated from Streptomyces lavendulae, shows potent anti-proliferation…
Treatment of (-)-saframycin A (1a) with selenium oxide in acetic acid afforded (-)-saframycin G (1g), and a catalytic reduction…
Saframycins Yd-1 and Y3, which have an amino functional group in the side chain, were recently obtained by a directed…
The chemical structure and conformation of the new antitumor antibiotic saframycin R have been determined by high field 1H and…
The quinone antitumor antibiotics saframycins A and C bind to duplex DNA and G,C containing complementary…
Saframycin S, structurally the decyano-saframycin A and biosynthetically the precursor of saframycin A, is a new antibiotic and…