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Two novel anti-emetic principles of Alpinia katsumadai.
Two novel diarylheptanoids isolated from the seeds of Alpinia katsumadai showed anti-emetic activities on copper sulfate-induced emesis in young chicks. Expand
TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation, and biological activities.
TMC-95A did not inhibit m-calpain, cathepsin L, and trypsin at 30 microM, suggesting its high selectivity for proteasome, and taxonomy of the producing strain is also described. Expand
DC-52, a novel antitumor antibiotic. 2. Isolation, physico-chemical characteristics and structure determination.
DC-52, C18H22N2O4, is a new antitumor antibiotic produced by Streptomyces melanovinaceus nov. sp. The structure of DC-52 has been determined by consideration of spectral data. It has the novelExpand
Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation.
Improved isolation methods are described along with identification of mikamycin A co-produced with leinamycin by the strain S-140, which was unstable in culture broth. Expand
Biological studies on the degradation products of 3-[(S)-1'-phenylethylamino]propylaminobleomycin: a novel analog (pepleomycin).
Results indicated much lower acute toxicity corresponding to the decreased in vitro activity when compared to PEP, and antimicrobial and anti-HeLa activities, inhibition of DNA synthesis in AH66 cells and the DNA strand cleavage. Expand
An active intermediate formed in the reaction of bleomycin-Fe(II) complex with oxygen.
The results suggest that oxygen adduct of BLM-Fe(II) is reduced by one electron transfer from an external electron donor and the resulting BLM-fe(III)-O2H- [or its deprotonated form: BLM- Fe(III-O2(2)-] shows the activity to break DNA accompanying the base-release. Expand
Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp.
Anti-herpesvirus activity of carbocyclic oxetanocin G in vitro.
Carbocyclic OXT-G showed much higher activity against TK+ HSV-2 than against a TK- mutant, suggesting that this compound is a good substrate for HSv-2-induced TK. Expand