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rontalizumab

Known as: Immunoglobulin G1, anti-(human interferons alpha type); humanized mouse monoclonal rhuMAB IFNalpha gamma1 heavy chain (des-CH3(sup 107)K, CH1(sup 97)R>K-IGHG1*03) (220-218')-disulfide with humanized mouse monoclonal rhuMAB IFNalpha kappa light chain, dimer (226-226'':229-229'')-bisdisulfide, RhuMAb IFNalpha 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Antibodies, Monoclonal, Humanized
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Why, why, why de-lupus (does so badly in clinical trials)
There is abundant evidence that B-lymphocytes play a major role in the development of lupus (reviewed in [1]). It thus seemed… 
2015
2015
Structural basis of the broadly neutralizing anti‐interferon‐α antibody rontalizumab
Interferons‐alpha (IFN‐α) are the expressed gene products comprising thirteen type I interferons with protein pairwise sequence… 
2014
2014
[Clinical and immunological factors of the onset and development of age-related macular degeneration].
UNLABELLED The purpose of the study is to determine the role of certain clinical and immunological factors of the onset and… 
Highly Cited
2012
Highly Cited
2012
Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo-controlled, double-blind, dose-escalation study.
OBJECTIVE Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies and… 
2009
2009
Treatment of Chronic Hepatitis C in a Patient Affected by Systemic Sclerosis
The currently recommended treatment for patients infected with hepatitis C virus (HCV) is pegilated interferon α (IFN α) plus… 
Highly Cited
2005
Highly Cited
2005
Overexpression and purification of recombinant human interferon alpha2b in Escherichia coli.
2001
2001
Astrocyte-Targeted Expression of Interleukin-3 and Interferon-α Causes Region-Specific Changes in Metallothionein Expression in the Brain
Transgenic mice expressing IL-3 and IFN-alpha under the regulatory control of the GFAP gene promoter (GFAP-IL3 and GFAP-IFNalpha… 
2000
2000
Opening the flood gates: interferon-alpha treatment for Sjögren's syndrome.
Interferon (IFN)-alpha is the main IFN produced in response to viral infection. Low levels of IFNalpha can be detected in nasal… 
2000
2000
Randomized controlled trial of twice-a-day administration of natural interferon beta for chronic hepatitis C.
We conducted a randomized controlled trial to assess the efficacy of twice-a-day administration of natural interferon beta… 
2000
2000
Interferon-alpha alone versus interferon-alpha plus ribavirin in patients with chronic hepatitis C not responding to previous interferon-alpha treatment.
OBJECTIVE To study the effects of monotherapy with leucocyte interferon-alpha (IFNalpha) versus IFNalpha + ribavirin in patients… 
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