• Corpus ID: 6664942

Opening the flood gates: interferon-alpha treatment for Sjögren's syndrome.

  title={Opening the flood gates: interferon-alpha treatment for Sj{\"o}gren's syndrome.},
  author={Shunichi Shiozawa and Joseph M. Cummins and Philip C. Fox},
  journal={BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy},
  volume={13 5},
  • S. Shiozawa, J. Cummins, P. Fox
  • Published 2000
  • Medicine, Biology
  • BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
Interferon (IFN)-alpha is the main IFN produced in response to viral infection. Low levels of IFNalpha can be detected in nasal secretions after exposure to viruses in vivo. Radioimmunoassay has shown that endogenous IFNalpha is low in children, reaches a peak in young adults, and gradually declines with aging. Importantly, this endogenous IFNalpha is significantly decreased in patients with Sjögren's syndrome (SS). IFNalpha has been tested as a therapeutic agent in patients with SS… 
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