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ribociclib

Known as: 7-Cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 
An orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential… Expand
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
BACKGROUND An earlier analysis of this phase 3 trial showed that the addition of a cyclin-dependent kinase 4 and 6 (CDK4/6… Expand
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Review
2018
Review
2018
Deregulation of the cyclin D‐CDK4/6‐INK4‐RB pathway leading to uncontrolled cell proliferation, is frequently observed in breast… Expand
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Highly Cited
2018
Highly Cited
2018
Purpose This phase III study evaluated ribociclib plus fulvestrant in patients with hormone receptor-positive/human epidermal… Expand
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Highly Cited
2018
Highly Cited
2018
BACKGROUND In MONALEESA-2, ribociclib plus letrozole showed improved progression-free survival compared with letrozole alone as… Expand
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Highly Cited
2018
Highly Cited
2018
Background The phase III MONALEESA-2 study demonstrated significantly prolonged progression-free survival (PFS) and a manageable… Expand
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Highly Cited
2018
Highly Cited
2018
  • The New England journal of medicine
  • 2018
  • Corpus ID: 58662368
 
Is this relevant?
Highly Cited
2016
Highly Cited
2016
BACKGROUND The inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) could potentially overcome or delay resistance to… Expand
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Review
2016
Review
2016
Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery and activation of cyclin-dependent… Expand
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Highly Cited
2016
Highly Cited
2016
Purpose: Ribociclib (an oral, highly specific cyclin-dependent kinase 4/6 inhibitor) inhibits tumor growth in preclinical models… Expand
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Highly Cited
2016
Highly Cited
2016
OBJECTIVES Cyclin D-cyclin-dependent kinase (CDK) 4/6-inhibitor of CDK4/6-retinoblastoma (Rb) pathway hyperactivation is… Expand
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