LEE011

Known as: LEE-011 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2013-2017
051020132017

Papers overview

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2018
2018
BACKGROUND/AIM Cyclin-dependent kinases (CDKs) are crucial for cell cycle regulation, and alterations in the cell cycle are often… (More)
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2017
2017
Purpose: The cyclin-dependent kinase (CDK) 4/6 inhibitor, ribociclib (LEE011), displayed preclinical activity in neuroblastoma… (More)
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2017
2017
Overexpression of cyclin D1 dependent kinases 4 and 6 (CDK4/6) is a common feature of many human cancers including leukemia… (More)
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2016
2016
PURPOSE Ribociclib (an oral, highly specific cyclin-dependent kinase 4/6 inhibitor) inhibits tumor growth in preclinical models… (More)
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2016
2016
OBJECTIVES Cyclin D-cyclin-dependent kinase (CDK) 4/6-inhibitor of CDK4/6-retinoblastoma (Rb) pathway hyperactivation is… (More)
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2015
2015
Dermatofibrosarcoma protuberans (DFSP) is an aggressive PDGFB-dependent cutaneous sarcoma characterized by infiltrative growth… (More)
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2015
2015
Several selective CDK4/6 inhibitors are in clinical trials for non-small cell lung cancer (NSCLC). Palbociclib (PD0332991) is… (More)
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2014
2014
143 Background: Activation of the PI3K/AKT/mTOR and cyclin D-CDK4/6-INK4-Rb pathways has been implicated in endocrine therapy… (More)
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2014
2014
Well-differentiated/dedifferentiated liposarcomas (WD/DDLPS) are among the most common subtypes of soft tissue sarcomas… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and mortality. Recently, a number of… (More)
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