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rhuMAb Beta7

Known as: Anti-Beta7, ETROLIZUMAB, Immunoglobulin G1, anti-(human integrin alpha4beta7/integrin alphaEbeta7) (human-rat monoclonal rhuMAb beta7 heavy chain), disulfide with human-rat monoclonal rhuMAb beta7 light chain, Dimer 
A humanized monoclonal antibody targeting the beta7 subunit of the heterodimeric integrins alpha4beta7 and alphaEbeta7, with anti-inflammatory… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Antibodies, Monoclonal, Humanized
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
AlphaE Integrin Expression Is Increased in the Ileum Relative to the Colon and Unaffected by Inflammation
Abstract Background Recent findings suggest that αE expression is enriched on effector T cells and that intestinal αE+ T cells… 
Review
2017
Review
2017
Emerging treatments for ulcerative colitis: a systematic review
Abstract Objectives: Various investigational medicinal products have been developed for ulcerative colitis (UC). Our aim was to… 
Review
2016
Review
2016
Assessment of Disease‐Related Therapeutic Protein Drug‐Drug Interaction for Etrolizumab in Patients With Moderately to Severely Active Ulcerative Colitis
The efficacy and safety of etrolizumab, a humanized IgG1 mAb, were evaluated in patients with ulcerative colitis (UC) in a phase… 
Review
2014
Review
2014
T-Cell Trafficking and Anti-Adhesion Strategies in Inflammatory Bowel Disease: Current and Future Prospects
The medical management of idiopathic inflammatory bowel disease (IBD) has historically been based upon the use of broad-spectrum… 
Review
2014
Review
2014
Risk of infections of biological therapies with accent on inflammatory bowel disease.
BACKGROUND Biological therapies using anti-tumor necrosis factor (TNF)-α agents have an important impact in the treatment of… 
2014
2014
Etrolizumab: anti-β7-a novel therapy for ulcerative colitis.
2014
2014
Targeting of gut specific leucocyte recruitment in IBD by vedolizumab
IBD is characterised by an inappropriate immune response to our own gut microbiota in the setting of a genetically susceptible… 
2006
2006
Enhanced FTY720-Mediated Lymphocyte Homing Requires Gαi Signaling and Depends on β2 and β7 Integrin1
The immunomodulatory drug FTY720 interferes with sphingosine-1-phosphate (S1P) receptor signaling leading to lymphocyte retention… 
2000
2000
Trichuris muris: CD4+ T cell-mediated protection in reconstituted SCID mice
Resistance to the murine intestinal nematode Trichuris muris requires the development of a strong Th2 response. In a… 
2000
2000
Beta7 integrins contribute to demyelinating disease of the central nervous system.
A role for alpha4 integrins in different forms of the multiple sclerosis-like disease experimental autoimmune encephalomyelitis… 
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