Beta7 integrins contribute to demyelinating disease of the central nervous system.

@article{Kanwar2000Beta7IC,
  title={Beta7 integrins contribute to demyelinating disease of the central nervous system.},
  author={J. R. Kanwar and Jessamina E. Harrison and Dunjing Wang and Eva Y Leung and Wolf H. M{\"u}ller and Norbert Wagner and Geoffrey Wayne Krissansen},
  journal={Journal of neuroimmunology},
  year={2000},
  volume={103 2},
  pages={146-52}
}
A role for alpha4 integrins in different forms of the multiple sclerosis-like disease experimental autoimmune encephalomyelitis (EAE) has been demonstrated, but the individual contributions of alpha4beta1, alpha4beta7, and the related alphaEbeta7 integrin have not been determined. The P7 integrins alpha4beta7 and alphaEbeta7 play a central role in chronic inflammation, mediating the trafficking, entry, and/or adhesion of lymphocytes in the inflamed pancreas and gut, and their ligands MAdCAM-1… CONTINUE READING
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