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rhizoxin
A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit…
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National Institutes of Health
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Related topics
Related topics
11 relations
Broader (4)
Antibiotics, Antineoplastic
Antifungal Agents
Macrolides
Tubulin Modulators
Microtubule Process
Microtubules
NCIt Antineoplastic Agent Terminology
Negative Regulation of Microtubule Polymerization
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Narrower (1)
WF-1360
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Asymmetric total synthesis of the immunosuppressant (-)-pironetin.
Cyril Bressy
,
J. Vors
,
Stefan Hillebrand
,
S. Arseniyadis
,
J. Cossy
Angewandte Chemie
2008
Corpus ID: 205350470
2006
2006
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
T. Yanagawa
,
T. Noguchi
,
H. Miyachi
,
Hisayoshi Kobayashi
,
Y. Hashimoto
Bioorganic & Medicinal Chemistry Letters
2006
Corpus ID: 23655741
Highly Cited
2000
Highly Cited
2000
Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts.
Michel Roberge
,
Bruno Cinel
,
+6 authors
Raymond J. Andersen
Cancer Research
2000
Corpus ID: 20400768
We describe a cell-based assay for antimitotic compounds that is suitable for drug discovery and for quantitative determination…
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1998
1998
Synthetic Studies of Antitumor Macrolide Rhizoxin: Stereoselective Syntheses of the C(1)-C(9) and C(12)-C(26) Subunits.
S. D. Burke
,
Jian Hong
,
J. R. Lennox
,
A. P. Mongin
Journal of Organic Chemistry
1998
Corpus ID: 32779776
A triply convergent synthetic approach which culminates in the enantioselective syntheses of the C(1)-C(9) and C(12)-C(26…
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1996
1996
Cryptophycin 1 binds to tubulin at a site distinct from the colchicine binding site and at a site that may overlap the vinca binding site.
S. Mooberry
,
C. Taoka
,
L. Busquets
Cancer Letters
1996
Corpus ID: 22728252
1996
1996
Enhanced Tumor Delivery and Antitumor Activity of Palmitoyl Rhizoxin Using Stable Lipid Emulsions in Mice
A. Kurihara
,
Y. Shibayama
,
+5 authors
M. Hisaoka
Pharmaceutical Research
1996
Corpus ID: 25951756
AbstractPurpose. A highly lipophilic antitumor agent, 13-O-palmitoyl-rhizoxin (RS-1541), was incorporated into lipid emulsions of…
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1993
1993
Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures.
P. Pizão
,
G. Peters
,
+5 authors
G. Giaccone
European Journal of Cancer
1993
Corpus ID: 36874838
1992
1992
Phase I and pharmacokinetic study of rhizoxin.
D. Bissett
,
M. Graham
,
+7 authors
S. Kaye
Cancer Research
1992
Corpus ID: 9450298
Rhizoxin is a tubulin-binding cytotoxic compound, isolated from the fungus Rhizopus chinensis, with significant antineoplastic…
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1992
1992
Preclinical and phase I studies with rhizoxin to apply a pharmacokinetically guided dose-escalation scheme.
M. Graham
,
D. Bissett
,
+4 authors
S. Kaye
Journal of the National Cancer Institute
1992
Corpus ID: 32571259
BACKGROUND Rhizoxin is a new macrocyclic lactone isolated from the fungus Rhizopus chinensis which displays broad-spectrum…
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1990
1990
Interaction of rhizoxin with bovine brain tubulin.
A. Sullivan
,
V. Prasad
,
M. C. Roach
,
M. Takahashi
,
S. Iwasaki
,
R. Luduena
Cancer Research
1990
Corpus ID: 6407277
Rhizoxin is an antitumor drug prepared from the fungus Rhizopus chinensis. It is an inhibitor of microtubule assembly and a…
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