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rhizoxin

A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit… Expand
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
The products synthesized from a hybrid polyketide synthase/nonribosomal peptide synthetase gene cluster in the genome of… Expand
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Highly Cited
2007
Highly Cited
2005
Highly Cited
2005
A number of plant pathogenic fungi belonging to the genus Rhizopus are infamous for causing rice seedling blight. This plant… Expand
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Highly Cited
1995
Highly Cited
1995
Trypanosoma brucei has a precisely ordered microtubule cytoskeleton whose morphogenesis is central to cell cycle events such as… Expand
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Review
1992
Review
1992
  • Ernest Hamel
  • Pharmacology & therapeutics
  • 1992
  • Corpus ID: 44835820
This paper summarizes published data on the interactions of tubulin with antimitotic compounds that inhibit the binding of vinca… Expand
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Highly Cited
1991
Highly Cited
1991
Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60… Expand
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Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly, tubulin-dependent GTP… Expand
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Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was isolated from the marine shell-less… Expand
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1987
1987
The binding of rhizoxin, a potent inhibitor of mitosis and in vitro microtubule assembly, to porcine brain tubulin was studied… Expand
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1984
1984
A new 16-membered macrolide designated as rhizoxin was isolated as a toxin produced by Rhizopus chinensis, the causal agent of… Expand
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