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rhizoxin

A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (4)

Antibiotics, AntineoplasticAntifungal AgentsMacrolidesTubulin Modulators
Microtubule ProcessMicrotubulesNCIt Antineoplastic Agent TerminologyNegative Regulation of Microtubule Polymerization

Narrower (1)

WF-1360

Papers overview

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2008
2008
Asymmetric total synthesis of the immunosuppressant (-)-pironetin.
2006
2006
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
Review
2003
Review
2003
Antimicrotubular drugs binding to vinca domain of tubulin
Studies on vinca domain binding drugs were done in great details by a number of workers as it is recognized as a potential target… 
Highly Cited
2000
Highly Cited
2000
Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts.
We describe a cell-based assay for antimitotic compounds that is suitable for drug discovery and for quantitative determination… 
1996
1996
Cryptophycin 1 binds to tubulin at a site distinct from the colchicine binding site and at a site that may overlap the vinca binding site.
1993
1993
Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures.
1992
1992
Phase I and pharmacokinetic study of rhizoxin.
Rhizoxin is a tubulin-binding cytotoxic compound, isolated from the fungus Rhizopus chinensis, with significant antineoplastic… 
1992
1992
Preclinical and phase I studies with rhizoxin to apply a pharmacokinetically guided dose-escalation scheme.
BACKGROUND Rhizoxin is a new macrocyclic lactone isolated from the fungus Rhizopus chinensis which displays broad-spectrum… 
1990
1990
Interaction of rhizoxin with bovine brain tubulin.
Rhizoxin is an antitumor drug prepared from the fungus Rhizopus chinensis. It is an inhibitor of microtubule assembly and a… 
Highly Cited
1987
Highly Cited
1987
Rhizoxin binding to tubulin at the maytansine-binding site.
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