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rhizoxin

A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (4)

Antibiotics, AntineoplasticAntifungal AgentsMacrolidesTubulin Modulators
Microtubule ProcessMicrotubulesNCIt Antineoplastic Agent TerminologyNegative Regulation of Microtubule Polymerization

Narrower (1)

WF-1360

Papers overview

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Highly Cited
2010
Highly Cited
2010
Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line.
Shift work: Biochemical analysis of the rhizoxin pathway revealed that the diene moiety is not shifted all at once, but through… 
Highly Cited
2008
Highly Cited
2008
Isolation and Identification of Rhizoxin Analogs from Pseudomonas fluorescens Pf-5 by Using a Genomic Mining Strategy
ABSTRACT The products synthesized from a hybrid polyketide synthase/nonribosomal peptide synthetase gene cluster in the genome of… 
Highly Cited
2007
Highly Cited
2007
A Gene Cluster Encoding Rhizoxin Biosynthesis in “Burkholderia rhizoxina”, the Bacterial Endosymbiont of the Fungus Rhizopus microsporus
riculture. 2] The causal agent of the disease has been isolated from cultures of the fungus Rhizopus microsporus, and it was… 
Highly Cited
2006
Highly Cited
2006
Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus.
The potent antimitotic polyketide macrolide rhizoxin, the causal agent of rice seedling blight, is not produced by the fungus… 
Highly Cited
2005
Highly Cited
2005
Pathogenic fungus harbours endosymbiotic bacteria for toxin production
A number of plant pathogenic fungi belonging to the genus Rhizopus are infamous for causing rice seedling blight. This plant… 
Highly Cited
1994
Highly Cited
1994
Interaction of ustiloxin A with bovine brain tubulin.
Highly Cited
1991
Highly Cited
1991
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
Highly Cited
1990
Highly Cited
1990
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
Highly Cited
1984
Highly Cited
1984
Studies on macrocyclic lactone antibiotics. VII. Structure of a phytotoxin "rhizoxin" produced by Rhizopus chinensis.
A new 16-membered macrolide designated as rhizoxin was isolated as a toxin produced by Rhizopus chinensis, the causal agent of… 
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