Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 210,024,294 papers from all fields of science
Search
Sign In
Create Free Account
rhizoxin
A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
11 relations
Broader (4)
Antibiotics, Antineoplastic
Antifungal Agents
Macrolides
Tubulin Modulators
Microtubule Process
Microtubules
NCIt Antineoplastic Agent Terminology
Negative Regulation of Microtubule Polymerization
Expand
Narrower (1)
WF-1360
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Functionally distinct modules operate two consecutive alpha,beta-->beta,gamma double-bond shifts in the rhizoxin polyketide assembly line.
Björn Kusebauch
,
B. Busch
,
K. Scherlach
,
M. Roth
,
C. Hertweck
Angewandte Chemie
2010
Corpus ID: 22771183
Shift work: Biochemical analysis of the rhizoxin pathway revealed that the diene moiety is not shifted all at once, but through…
Expand
Highly Cited
2008
Highly Cited
2008
Isolation and Identification of Rhizoxin Analogs from Pseudomonas fluorescens Pf-5 by Using a Genomic Mining Strategy
J. Loper
,
M. D. Henkels
,
B. Shaffer
,
F. Valeriote
,
H. Gross
Applied and Environmental Microbiology
2008
Corpus ID: 2538604
ABSTRACT The products synthesized from a hybrid polyketide synthase/nonribosomal peptide synthetase gene cluster in the genome of…
Expand
Highly Cited
2007
Highly Cited
2007
A Gene Cluster Encoding Rhizoxin Biosynthesis in “Burkholderia rhizoxina”, the Bacterial Endosymbiont of the Fungus Rhizopus microsporus
L. Partida-Martínez
,
C. Hertweck
ChemBioChem
2007
Corpus ID: 30150994
riculture. 2] The causal agent of the disease has been isolated from cultures of the fungus Rhizopus microsporus, and it was…
Expand
Highly Cited
2006
Highly Cited
2006
Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus.
K. Scherlach
,
L. Partida-Martínez
,
H. Dahse
,
C. Hertweck
Journal of the American Chemical Society
2006
Corpus ID: 11186718
The potent antimitotic polyketide macrolide rhizoxin, the causal agent of rice seedling blight, is not produced by the fungus…
Expand
Highly Cited
2005
Highly Cited
2005
Pathogenic fungus harbours endosymbiotic bacteria for toxin production
L. Partida-Martínez
,
C. Hertweck
Nature
2005
Corpus ID: 4416437
A number of plant pathogenic fungi belonging to the genus Rhizopus are infamous for causing rice seedling blight. This plant…
Expand
Highly Cited
1994
Highly Cited
1994
Interaction of ustiloxin A with bovine brain tubulin.
R. Luduena
,
M. C. Roach
,
+4 authors
S. Iwasaki
Biochemical Pharmacology
1994
Corpus ID: 28687688
Highly Cited
1991
Highly Cited
1991
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
R. Bai
,
K. Paull
,
C. L. Herald
,
L. Malspeis
,
G. Pettit
,
E. Hamel
Journal of Biological Chemistry
1991
Corpus ID: 20103295
Highly Cited
1990
Highly Cited
1990
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
R. Bai
,
G. Pettit
,
E. Hamel
Journal of Biological Chemistry
1990
Corpus ID: 21148141
Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
R. Bai
,
G. Pettit
,
E. Hamel
Biochemical Pharmacology
1990
Corpus ID: 24709782
Highly Cited
1984
Highly Cited
1984
Studies on macrocyclic lactone antibiotics. VII. Structure of a phytotoxin "rhizoxin" produced by Rhizopus chinensis.
S. Iwasaki
,
H. Kobayashi
,
+5 authors
T. Noda
Journal of antibiotics (Tokyo. )
1984
Corpus ID: 11898771
A new 16-membered macrolide designated as rhizoxin was isolated as a toxin produced by Rhizopus chinensis, the causal agent of…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE