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rhizoxin

A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit… Expand
National Institutes of Health

Related topics

Related topics

11 relations

Broader (4)

Antibiotics, AntineoplasticAntifungal AgentsMacrolidesTubulin Modulators
Microtubule ProcessMicrotubulesNCIt Antineoplastic Agent TerminologyNegative Regulation of Microtubule Polymerization
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Narrower (1)

WF-1360

Papers overview

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Highly Cited
2008
Highly Cited
2008
Isolation and Identification of Rhizoxin Analogs from Pseudomonas fluorescens Pf-5 by Using a Genomic Mining Strategy
ABSTRACT The products synthesized from a hybrid polyketide synthase/nonribosomal peptide synthetase gene cluster in the genome of… Expand
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Highly Cited
2007
Highly Cited
2007
A Gene Cluster Encoding Rhizoxin Biosynthesis in “Burkholderia rhizoxina”, the Bacterial Endosymbiont of the Fungus Rhizopus microsporus
riculture. 2] The causal agent of the disease has been isolated from cultures of the fungus Rhizopus microsporus, and it was… Expand
Highly Cited
2005
Highly Cited
2005
Pathogenic fungus harbours endosymbiotic bacteria for toxin production
A number of plant pathogenic fungi belonging to the genus Rhizopus are infamous for causing rice seedling blight. This plant… Expand
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Highly Cited
2003
Highly Cited
2003
Enantioselective total synthesis of the antitumor macrolide rhizoxin D.
The convergent, highly enantioselective synthesis of rhizoxin D, a natural product possessing potent antitumor and antifungal… Expand
Highly Cited
1995
Highly Cited
1995
Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle
Trypanosoma brucei has a precisely ordered microtubule cytoskeleton whose morphogenesis is central to cell cycle events such as… Expand
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Review
1992
Review
1992
Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B.
  • E. Hamel
  • Pharmacology & therapeutics
  • 1992
    • Corpus ID: 44835820
This paper summarizes published data on the interactions of tubulin with antimitotic compounds that inhibit the binding of vinca… Expand
Highly Cited
1991
Highly Cited
1991
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60… Expand
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Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was isolated from the marine shell-less… Expand
Highly Cited
1987
Highly Cited
1987
Rhizoxin binding to tubulin at the maytansine-binding site.
The binding of rhizoxin, a potent inhibitor of mitosis and in vitro microtubule assembly, to porcine brain tubulin was studied… Expand
Highly Cited
1984
Highly Cited
1984
Studies on macrocyclic lactone antibiotics. VII. Structure of a phytotoxin "rhizoxin" produced by Rhizopus chinensis.
A new 16-membered macrolide designated as rhizoxin was isolated as a toxin produced by Rhizopus chinensis, the causal agent of… Expand
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