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rhizoxin

A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
ABSTRACT The products synthesized from a hybrid polyketide synthase/nonribosomal peptide synthetase gene cluster in the genome of… Expand
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Highly Cited
2007
Highly Cited
2007
riculture. 2] The causal agent of the disease has been isolated from cultures of the fungus Rhizopus microsporus, and it was… Expand
Highly Cited
2005
Highly Cited
2005
A number of plant pathogenic fungi belonging to the genus Rhizopus are infamous for causing rice seedling blight. This plant… Expand
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Highly Cited
2003
Highly Cited
2003
The convergent, highly enantioselective synthesis of rhizoxin D, a natural product possessing potent antitumor and antifungal… Expand
Highly Cited
1995
Highly Cited
1995
Trypanosoma brucei has a precisely ordered microtubule cytoskeleton whose morphogenesis is central to cell cycle events such as… Expand
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Review
1992
Review
1992
  • E. Hamel
  • Pharmacology & therapeutics
  • 1992
  • Corpus ID: 44835820
This paper summarizes published data on the interactions of tubulin with antimitotic compounds that inhibit the binding of vinca… Expand
Highly Cited
1991
Highly Cited
1991
Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60… Expand
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Highly Cited
1990
Highly Cited
1990
Dolastatin 10, a cytostatic peptide containing several unique amino acid subunits, was isolated from the marine shell-less… Expand
Highly Cited
1987
Highly Cited
1987
The binding of rhizoxin, a potent inhibitor of mitosis and in vitro microtubule assembly, to porcine brain tubulin was studied… Expand
Highly Cited
1984
Highly Cited
1984
A new 16-membered macrolide designated as rhizoxin was isolated as a toxin produced by Rhizopus chinensis, the causal agent of… Expand