FAQ

rhizoxin

A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2016
051019842016

Related topics

Related topics

10 relations

Broader (4)

Antibiotics, AntineoplasticAntifungal AgentsMacrolidesTubulin Modulators
Microtubule ProcessMicrotubulesNegative Regulation of Microtubule PolymerizationNegative Regulation of Mitosis
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Narrower (1)

WF-1360

Related mentions per year

Related mentions per year

1945-2018
19401960198020002020
rhizoxin
Microtubules
Antifungal Agents
Macrolides
Tubulin
Antibiotics, Antineoplastic

Papers overview

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2006
2006
Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus.
The potent antimitotic polyketide macrolide rhizoxin, the causal agent of rice seedling blight, is not produced by the fungus… (More)
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Highly Cited
2005
Highly Cited
2005
Pathogenic fungus harbours endosymbiotic bacteria for toxin production
A number of plant pathogenic fungi belonging to the genus Rhizopus are infamous for causing rice seedling blight. This plant… (More)
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Highly Cited
1999
Highly Cited
1999
Evidence for novel cell cycle checkpoints in trypanosomes: kinetoplast segregation and cytokinesis in the absence of mitosis.
Trypanosoma brucei has a single nucleus and a single kinetoplast (the mitochondrial genome). Each of these organelles has a… (More)
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Highly Cited
1995
Highly Cited
1995
Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle
Trypanosoma brucei has a precisely ordered microtubule cytoskeleton whose morphogenesis is central to cell cycle events such as… (More)
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1992
1992
Phase I and pharmacokinetic study of rhizoxin.
Rhizoxin is a tubulin-binding cytotoxic compound, isolated from the fungus Rhizopus chinensis, with significant antineoplastic… (More)
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Highly Cited
1991
Highly Cited
1991
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
Data generated in the new National Cancer Institute drug evaluation program, which is based on inhibition of cell growth in 60… (More)
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1990
1990
Interaction of rhizoxin with bovine brain tubulin.
Rhizoxin is an antitumor drug prepared from the fungus Rhizopus chinensis. It is an inhibitor of microtubule assembly and a… (More)
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1987
1987
Rhizoxin binding to tubulin at the maytansine-binding site.
The binding of rhizoxin, a potent inhibitor of mitosis and in vitro microtubule assembly, to porcine brain tubulin was studied… (More)
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1986
1986
Rhizoxin, a macrocyclic lactone antibiotic, as a new antitumor agent against human and murine tumor cells and their vincristine-resistant sublines.
Rhizoxin, isolated from a plant pathogenic fungus which causes rice seedling blight, inhibits the mitosis of the tumor cells in a… (More)
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1984
1984
Studies on macrocyclic lactone antibiotics. VII. Structure of a phytotoxin "rhizoxin" produced by Rhizopus chinensis.
A new 16-membered macrolide designated as rhizoxin was isolated as a toxin produced by Rhizopus chinensis, the causal agent of… (More)
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