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rhazinilam

Known as: Indolizino(8,1-ef)(1)benzazonin-6(5H)-one, 8a-ethyl-7,8,8a,9,10,11-hexahydro-, (8aR-(8aR*,14aR*))- 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

AlkaloidsIndolizinesLactams

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Chemical synthesis of Aspidosperma alkaloids inspired by the reverse of the biosynthesis of the rhazinilam family of natural products.
Pyrrole and pyrroldine heterocycles are ubiquitous structural features in natural products. Nature’s biosynthetic machinery often… 
Highly Cited
2010
Highly Cited
2010
Total synthesis of rhazinilam: axial to point chirality transfer in an enantiospecific Pd-catalyzed transannular cyclization.
A total synthesis of rhazinilam based on a transannular cyclization strategy is described. Using a Heck reaction, the axial… 
2007
2007
A new synthetic approach to biaryls of the rhazinilam type. Application to synthesis of three novel phenylpyridine-carbamate analogues.
The synthesis of three novel racemic phenylpyridine-carbamate analogues of rhazinilam and their biological evaluation as… 
Highly Cited
2005
Highly Cited
2005
Concise synthesis of (+/-)-rhazinilam through direct coupling.
[reaction: see text] A concise synthesis of rhazinilam through direct, palladium-catalyzed, intramolecular coupling is described. 
2005
2005
Conformational analysis of rhazinilam and three-dimensional quantitative structure-activity relationships of rhazinilam analogues.
2002
2002
Synthesis and biological evaluation of A-ring biaryl-carbamate analogues of rhazinilam.
2001
2001
First total synthesis of phenylpyridine analogues of the antimitotic rhazinilam.
The first synthesis of phenylpyridine analogues of rhazinilam and evaluation of these new structures as inhibitors of microtubule… 
Highly Cited
1994
Highly Cited
1994
Rhazinilam mimics the cellular effects of taxol by different mechanisms of action.
We have investigated the effects of the microtubule poison rhazinilam on microtubule assembly in vivo and in vitro. In mammalian… 
Review
1991
Review
1991
Looking for new drugs: what criteria?
1973
1973
Biological and phytochemical evaluation of plants. XI. Isolation of aspidospermine, quebrachidine, rhazinilam, (-)-pyrifolidine, and akuammidine from Aspidosperma quebracho-blanco (Apocynaceae).
A phytochemical investigation of the leaves of Aspidosperma quebracho-blanco (Apocynaceae) resulted in the isolation of… 
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