• Publications
  • Influence
Recent advances in the investigation of curcuminoids
The literature between 1976 and mid-2008 on the anti-inflammatory, anti-oxidant,Anti-HIV, chemopreventive and anti-prostate cancer effects of curcuminoids are reviewed.
Plant-derived natural product research aimed at new drug discovery
Research on many different useful compounds isolated or developed from plants with emphasis placed on those recently discovered by the authors’ laboratories as antitumor and anti-HIV clinical trial candidates are summarized.
Structures and cytotoxic activity relationship of casearins, new clerodane diterpenes from Casearia sylvestris Sw.
Casearins G-R, new cytotoxic clerodane diterpenes have been isolated from the leaves of Casearia sylvestris Sw. (Flacourtiaceae). Their structures have been elucidated by spectroscopic methods and
Studies on the Constituents of the Seeds of Alpinia katsumadai HAYATA
Four new diarylheptanoids [(5R)-trans-1, 7-diphenyl-5-hydroxy-6-hepten-3-one (VIIa), (3S, 5S)-trans-1, 7-diphenyl-3, 5-dihydroxy-1-heptene (VIIIa), trans-1, 7-diphenyl-5-hydroxy-1-heptene (IX) and
Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca.
The isolation and structure elucidation of four cytotoxic aromatic triterpenes [1-4] along with three known quinoid triterpenes [5-7] from the South American medicinal plants Maytenus ilicifolia and
Anthraquinones, naphthohydroquinones and naphthohydroquinone dimers from Rubia cordifolia and their cytotoxic activity.
Further investigation of the roots of Rubia cordifolia resulted in the isolation of four new naphthohydroquinones and two naphthaquinone dimers and the structures of these compounds were established by various chemical and spectroscopic methods including two dimensional NMR techniques.