response to stem cell factor

Known as: response to KIT ligand, response to hematopoietic growth factor KL, response to SCF 
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene… (More)
National Institutes of Health

Papers overview

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2011
2011
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
Src homology 2 domain-containing phosphatase 2 (Shp2), encoded by Ptpn11, is a member of the nonreceptor protein-tyrosine… (More)
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Highly Cited
2007
Highly Cited
2007
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells.
Defining how cancer-associated mutations perturb signaling networks in stem/progenitor populations that are integral to tumor… (More)
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Highly Cited
2005
Highly Cited
2005
KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.
KIT exon 8 mutations are located in the extracellular portion of the receptor and are strongly associated with core-binding… (More)
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Highly Cited
2001
Highly Cited
2001
Signaling through extracellular signal-regulated kinase is required for spermatogonial proliferative response to stem cell factor.
In vitro addition of stem cell factor (SCF) to c-kit-expressing A(1)-A(4) spermatogonia from prepuberal mice stimulates their… (More)
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Highly Cited
2000
Highly Cited
2000
Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571
Small cell lung cancer (SCLC) is an aggressive cancer characterized by several autocrine growth mechanisms including stem cell… (More)
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Highly Cited
1999
Highly Cited
1999
Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction
In this report we show that Tyr568 and Tyr570 are phosphorylated in vivo in the Kit/stem cell factor receptor (Kit/SCFR… (More)
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1997
1997
Stat1 associates with c-kit and is activated in response to stem cell factor.
Interaction of stem cell factor (SCF), a haematopoietic growth factor, with the receptor tyrosine kinase c-kit leads to… (More)
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1996
1996
JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor.
Stem cell factor (SCF) interacts with the receptor tyrosine kinase c-Kit and has potent effects on hematopoiesis. We have… (More)
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1994
1994
Rapid exit from G0/G1 phases of cell cycle in response to stem cell factor confers on umbilical cord blood CD34+ cells an enhanced ex vivo expansion potential.
Currently, the most commonly used grafts of progenitor and stem cells for patients undergoing bone marrow transplantation (BMT… (More)
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Highly Cited
1993
Highly Cited
1993
Enhanced proliferative potential in culture of cells from p53-deficient mice.
Normal somatic cells are endowed with limited doubling potential in culture, and the process of immortalization is an inevitable… (More)
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