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The pu.1 promoter drives myeloid gene expression in zebrafish.
PU.1 is a member of the Ets family of transcription factors and plays an essential role in the development of both myeloid and lymphoid cells. To examine zebrafish pu.1 (zpu.1) expression inExpand
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Increased PTSD risk with combat-related injury: a matched comparison study of injured and uninjured soldiers experiencing the same combat events.
OBJECTIVE The aim of the present study was to isolate the unique contribution of physical injury to the subsequent development of posttraumatic stress disorder (PTSD). METHOD Participants were 60Expand
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CRISPR MultiTargeter: A Web Tool to Find Common and Unique CRISPR Single Guide RNA Targets in a Set of Similar Sequences
Genome engineering has been revolutionized by the discovery of clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR-associated system genes (Cas) in bacteria. The type IIBExpand
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Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination.
Mast cells (MCs) play critical roles in allergy and inflammation, yet their development remains controversial due to limitations posed by traditional animal models. The zebrafish provides a highlyExpand
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NUP98‐HOXA9‐transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis
NUP98‐HOXA9 [t(7;11) (p15;p15)] is associated with inferior prognosis in de novo and treatment‐related acute myeloid leukaemia (AML) and contributes to blast crisis in chronic myeloid leukaemiaExpand
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Zebrafish xenografts as a tool for in vivo studies on human cancer.
The zebrafish has become a powerful vertebrate model for genetic studies of embryonic development and organogenesis and increasingly for studies in cancer biology. Zebrafish facilitate theExpand
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Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.
Metastatic dissemination is the leading cause of death in cancer patients, which is particularly evident for high-risk sarcomas such as Ewing sarcoma, osteosarcoma, and rhabdomyosarcoma. PreviousExpand
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Zebrafish as a model for myelopoiesis during embryogenesis.
Zebrafish produce nearly identical hematopoeitic cell lineages to those found in mammals and other higher vertebrates. As in mammals, blood cell development proceeds in distinct waves, constitutingExpand
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Leukaemia xenotransplantation in zebrafish – chemotherapy response assay in vivo
As the molecular understanding of cancer pathogenesis has evolved, so has the need for innovative assays to identify novel targeted therapeutic agents. Characterization of specific tumour-drugExpand
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Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses.
We previously identified a zebrafish mast cell (MC) lineage and now aim to determine if these cells function analogously in innate and adaptive immunity like their mammalian counterparts.Expand
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