replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes… (More)
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease… (More)
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Review
2010
Review
2010
Aberrant DNA replication is a major source of the mutations and chromosome rearrangements that are associated with pathological… (More)
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Review
2010
Review
2010
Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several… (More)
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Highly Cited
2010
Highly Cited
2010
DNA replication starts at initiation sites termed replication origins. Metazoan cells contain many more potential origins than… (More)
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Highly Cited
2009
Highly Cited
2009
If replication forks are perturbed, a multifaceted response including several DNA repair and cell cycle checkpoint pathways is… (More)
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Highly Cited
2009
Highly Cited
2009
Replication forks face multiple obstacles that slow their progression. By two-dimensional gel analysis, yeast forks pause at… (More)
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Highly Cited
2008
Highly Cited
2008
DNA polymerase delta (Pol delta) and DNA polymerase epsilon (Pol epsilon) are both required for efficient replication of the… (More)
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Highly Cited
2006
Highly Cited
2006
DNA replication forks pause in front of lesions on the template, eventually leading to cytotoxic chromosomal rearrangements. The… (More)
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Highly Cited
2006
Highly Cited
2006
Unrepaired lesions in the DNA template pose a threat to accurate replication. Several pathways exist in Escherichia coli to… (More)
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Review
2005
Review
2005
DNA replicases are multicomponent machines that have evolved clever strategies to perform their function. Although the structure… (More)
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