replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2017
05019762017

Papers overview

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Highly Cited
2009
Highly Cited
2009
The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still poorly understood. We found… (More)
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Highly Cited
2008
Highly Cited
2008
A prevalent view of DNA replication has been that it is carried out in fixed "replication factories." By tracking the progression… (More)
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Highly Cited
2008
Highly Cited
2008
Previous studies have demonstrated essential roles for ATP-dependent chromatin-remodeling and chromatin-modifying enzymes in gene… (More)
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Highly Cited
2006
Highly Cited
2006
The components of the replisome that preserve genomic stability by controlling the progression of eukaryotic DNA replication… (More)
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Highly Cited
2005
Highly Cited
2005
Eukaryotic cells regulate the progression and integrity of DNA replication forks to maintain genomic stability and couple DNA… (More)
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Highly Cited
2005
Highly Cited
2005
Chromosome and replisome dynamics were examined in synchronized E. coli cells undergoing a eukaryotic-like cell cycle. Sister… (More)
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Highly Cited
2004
Highly Cited
2004
We here reconstitute a minimal mammalian mitochondrial DNA (mtDNA) replisome in vitro. The mtDNA polymerase (POLgamma) cannot use… (More)
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Highly Cited
2004
Highly Cited
2004
The replication checkpoint controls the integrity of replicating chromosomes by stabilizing stalled forks, thus preventing the… (More)
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Highly Cited
2003
Highly Cited
2003
The unit of inheritance for mitochondrial DNA (mtDNA) is a complex nucleoprotein structure termed the nucleoid. The organization… (More)
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Highly Cited
2000
Highly Cited
2000
We found that DNA is replicated at a central stationary polymerase, and each replicated region moves away from the replisome. In… (More)
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