Skip to search formSkip to main contentSkip to account menu

reduced folate carrier

Known as: Folate Carrier, Reduced, SLC19a1 Protein, Transporter 1, Folate 
A ubiquitously expressed folic acid transporter that functions via an antiporter mechanism which is coupled to the transport of organic phosphates.
National Institutes of Health

Related topics

Related topics

10 relations
In BloodProcess of secretionSLC19A1 wt Alleleagonists

Narrower (1)

SLC19A1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency.
Fumonisin B1 (FB1) induces apoptosis and decreases the cellular uptake of 5-methyltetrahydrofolate. Two folate transporters… 
2007
2007
Down‐regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism
Folate plays a critical role in maintaining normal metabolic, energy, differentiation and growth status of all mammalian cells… 
2006
2006
Role of reduced folate carrier in intestinal folate uptake.
Studies from our laboratory and others have characterized different aspects of the intestinal folate uptake process and have… 
2004
2004
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia
Although the majority of children with acute lymphoblastic leukemia (ALL) are cured with combination chemotherapy containing… 
Highly Cited
2004
Highly Cited
2004
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
A methotrexate (MTX)-resistant HeLa subline (R5), developed in this laboratory, with impaired transport due to a genomic deletion… 
Highly Cited
2003
Highly Cited
2003
Loss of Multidrug Resistance Protein 1 Expression and Folate Efflux Activity Results in a Highly Concentrative Folate Transport in Human Leukemia Cells*
We studied the molecular basis of the up to 46-fold increased accumulation of folates and methotrexate (MTX) in human leukemia… 
Highly Cited
2002
Highly Cited
2002
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
2001
2001
The Basal Promoters for the Human Reduced Folate Carrier Gene Are Regulated by a GC-box and a cAMP-response Element/AP-1-like Element
Our laboratory previously identified two functional promoters (designated A and B) for the human reduced folate carrier (hRFC… 
Highly Cited
1999
Highly Cited
1999
Impaired Membrane Transport in Methotrexate-resistant CCRF-CEM Cells Involves Early Translation Termination and Increased Turnover of a Mutant Reduced Folate Carrier*
The basis for impaired reduced folate carrier (RFC) activity in methotrexate-resistant CCRF-CEM (CEM/Mtx-1) cells was examined… 
Highly Cited
1997
Highly Cited
1997
Simultaneous activity of two different mechanisms of folate transport in ovarian carcinoma cell lines
We investigated whether the folate receptor α‐isoform (FRα), which is overexpressed on ovarian carcinoma cells, is functionally… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)