reduced folate carrier

Known as: Folate Carrier, Reduced, SLC19a1 Protein, Transporter 1, Folate 
A ubiquitously expressed folic acid transporter that functions via an antiporter mechanism which is coupled to the transport of organic phosphates.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The biologic basis of autism is complex and is thought to involve multiple and variable gene-environment interactions. While the… (More)
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Highly Cited
2008
Highly Cited
2008
The reduced folate carrier (RFC) and the proton-coupled folate transporter (PCFT) are ubiquitously expressed in normal and… (More)
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2006
2006
Studies from our laboratory and others have characterized different aspects of the intestinal folate uptake process and have… (More)
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Highly Cited
2005
Highly Cited
2005
Folate metabolism supports the synthesis of nucleotides as well as the transfer of methyl groups. Polymorphisms in folate… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Methotrexate (MTX) enters cells through the reduced folate carrier (RFC-1) and exerts part of its effects through… (More)
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2004
2004
BACKGROUND To evaluate the impact of dihydrofolate reductase (DHFR) and reduced folate carrier (RFC) genes on methotrexate (MTX… (More)
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Highly Cited
2002
Highly Cited
2002
The goals and objectives of these studies, conducted over the past 30 y, were to determine: a) how chronic alcoholism leads to… (More)
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1999
1999
The membrane topology of the human reduced folate carrier protein (591 amino acids) was assessed by single insertions of the… (More)
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1999
1999
Methotrexate (MTX) is one of the most active and widely used agents for the treatment of acute lymphoblastic leukemia (ALL). To… (More)
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Highly Cited
1998
Highly Cited
1998
CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective… (More)
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