ravuconazole

Known as: 3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol, p-(2-((alphaR,betaR)-2,4-Difluoro-beta-hydroxy-alpha-methyl-beta-(1H-1,2,4-triazol-1-ylmethyl)phenethyl)-4-thiazolyl)benzonitrile 
A triazole with antifungal activity. Ravuconazole inhibits 14a demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal… (More)
National Institutes of Health

Papers overview

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2014
2014
The current treatment of eumycetoma utilizing ketoconazole is unsatisfactory because of high recurrence rates, which often leads… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Resistance to triazoles was recently reported in Aspergillus fumigatus isolates cultured from patients with invasive… (More)
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2004
2004
Cross-resistance within a class of antimicrobial agents is a problem that is often encountered with antibacterial agents, and it… (More)
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Highly Cited
2003
Highly Cited
2003
We examined the in vitro activity of caspofungin, posaconazole, voriconazole, ravuconazole, itraconazole, and amphotericin B… (More)
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2003
2003
In vivo studies have characterized the pharmacodynamic characteristics of the triazole fluconazole. These investigations… (More)
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Highly Cited
2002
Highly Cited
2002
The in vitro activities of ravuconazole and voriconazole were compared with those of amphotericin B, flucytosine (5FC… (More)
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Highly Cited
2002
Highly Cited
2002
Posaconazole, ravuconazole, and voriconazole are new triazole derivatives that possess potent, broad-spectrum antifungal activity… (More)
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Review
2002
Review
2002
Eisai and Bristol-Myers Squibb (BMS) are developing the triazole, ravuconazole, as a potential treatment for fungal infection… (More)
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Highly Cited
2001
Highly Cited
2001
A surveillance program (SENTRY) of bloodstream infections (BSI) in the United States, Canada, Latin America, and Europe from 1997… (More)
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2000
2000
The in vitro activities of the new triazole, ravuconazole (BMS-207147), were compared to those of fluconazole and itraconazole… (More)
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