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quinacillin
Known as:
3-carboxy-2-quinoxalinylpenicillanic acid
A semisynthetic penicillase-resistant penicillin with antibacterial activity. Quinacillin binds to and inactivates penicillin-binding proteins (PBPs…
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National Institutes of Health
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Broader (1)
Penicillins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1987
1987
Kinetics and mechanism of inactivation of the RTEM-2 beta-lactamase by phenylpropynal. Identification of the characteristic chromophore.
M. Grace
,
D. Schenkein
,
R. Pratt
Journal of Biological Chemistry
1987
Corpus ID: 42000229
Highly Cited
1981
Highly Cited
1981
Inactivation of the RTEM beta-lactamase from Escherichia coli. Interaction of penam sulfones with enzyme.
J. Fisher
,
R. Charnas
,
S. Bradley
,
J. Knowles
Biochemistry
1981
Corpus ID: 43894138
The characteristics of the reaction of a number of mechanism-based inactivators of the RTEM beta-lactamase have suggested that a…
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1978
1978
Reversible inhibition of penicillinase by quinacillin: evaluation of mechanisms involving two conformational states of the enzyme.
R. Virden
,
A. Bristow
,
R. Pain
Biochemical and Biophysical Research…
1978
Corpus ID: 26454087
1975
1975
The active site of penicillinase from Staphylococcus aureus PC1. Isolation of a specific covalent complex with the substrate quinacillin.
R. Virden
,
A. Bristow
,
R. Pain
Biochemical Journal
1975
Corpus ID: 34112133
1. The penicillinase-catalysed hydrolysis of quinacillin was quenched by addition of 5 m-guanidinium chloride or 1% (w/v) sodium…
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1971
1971
Chemotherapeutic and toxicological properties of quinacillin.
R. G. Bough
,
R. Everest
,
L. J. Hale
,
B. Lessel
,
C. Mason
,
D. F. Spooner
Chemotherapy
1971
Corpus ID: 3275524
The disodium salt of quinacillin (3-carboxy-2-quinoxalinylpenicillin) is highly effective in protecting mice experimentally…
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1966
1966
The role of cellular lipid in the resistance of gram-positive bacteria to penicillins.
W. Hugo
,
R. Stretton
Journal of General Microbiology
1966
Corpus ID: 45938890
SUMMARY: It has been shown that when the Gram-positive micro-organisms Bacillus subtilis, Staphylococcus aureus and Streptococcus…
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1965
1965
Cephalosporinase and penicillinase activity of Gram-negative bacteria.
G. Ayliffe
Journal of General Microbiology
1965
Corpus ID: 35373412
SUMMARY: Sensitivity to ampicillin and cephalothin, the formation and induction of penicillinase and cephalosporinase, and the…
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Highly Cited
1964
Highly Cited
1964
Penicillinase-resistant Penicillins and Cephalosporins
M. Barber
,
P. Waterworth
British medical journal
1964
Corpus ID: 28067507
The discovery of penicillinase-resistant penicillins is an important landmark in the history of antibacterial chemotherapy…
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1964
1964
Action of Quinacillin on Staphylococcus aureus
W. Hugo
,
R. Stretton
Nature
1964
Corpus ID: 4198059
QUINACILLIN, the disodium salt of 3-carboxy-2-quinoxalinylpenicillin, has recently been described1,2 and has, for a penicillin…
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1964
1964
Quinacillin : A Comparison with other Penicillinase-Resistant Penicillins
J. Smith
,
J. Hamilton-miller
,
R. Knox
Nature
1964
Corpus ID: 35076259
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