• Publications
  • Influence
Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.
The 5'AMP-activated protein kinase (AMPK) is stimulated by contractile activity in rat skeletal muscle. AMPK has emerged as an important signaling intermediary in the regulation of cell metabolismExpand
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A Comparison of Manual Versus Computer‐Assisted Radiographic Measurement: Intraobserver Measurement Variability for Cobb Angles
Study Design. A comparison between computer‐assisted measurement using digitized radiographs, which has the potential to reduce error, and manual measurement using standard radiographs. Objective. ToExpand
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Nalidixic Acid: an Antibacterial Paradox
Nalidixic acid was found to be most bactericidal against various species of gram-negative bacteria at 50 to 200 μg/ml. With all species tested, increases in the concentration of nalidixic acid aboveExpand
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The mode of action of 4-quinolones and possible mechanisms of resistance.
  • J. Smith
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
  • 1 November 1986
Supercoiling of bacterial DNA, mediated by DNA gyrase, is essential to enable bacteria to accommodate their very long chromosomes within the cell envelope. Bacterial DNA gyrase, unlike the comparableExpand
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A Comparison of the Effects of Patient-Controlled Analgesia with Intravenous Opioids Versus Epidural Analgesia on Recovery After Surgery for Idiopathic Scoliosis
Study Design. Epidural infusion was compared with standard patient-controlled analgesia (PCA) in 50 patients after surgical correction of adolescent idiopathic scoliosis with respect to certainExpand
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The Volume of Lung Parenchyma as a Function of Age: A Review of 1050 Normal CT Scans of the Chest With Three-Dimensional Volumetric Reconstruction of the Pulmonary System
Study Design. An Institutional Review Board-approved retrospective review of 3400 sequential CT scans of the thorax obtained at a single institution over a 3-year period from 2000 to 2003 wasExpand
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Best Practices in Intraoperative Neuromonitoring in Spine Deformity Surgery: Development of an Intraoperative Checklist to Optimize Response.
STUDY DESIGN Consensus-based creation of a checklist and guideline. OBJECTIVE To develop a consensus-based checklist to guide surgeon responses to intraoperative neuromonitoring (IONM) changes inExpand
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A Longitudinal Study of the Development of Low Back Pain in an Industrial Population
Study Design. This is a longitudinal study in which industrial workers without chronic low back pain (LBP) were initially assessed with a comprehensive test battery and surveyed every 6 monthsExpand
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Trimethoprim Action and Its Analogy with Thymine Starvation
  • S. Amyes, J. Smith
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • 1 February 1974
In a minimal medium, trimethoprim is merely bacteriostatic on the prototroph Escherichia coli 114. The drug was bactericidal when the amino acids methionine and glycine, plus a purine or purineExpand
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The mode of action of quinolones: The paradox in activity of low and high concentrations and activity in the anaerobic environment
All 4-quinolones that have been examined display rapid bactericidal activity which is biphasic. At concentrations above the MIC, the lethality of the drugs increases until a concentration known asExpand
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