pyrazofurin

Known as: Pyrazole, -3-Carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl, 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-.beta.-D-ribofuranosyl- (9CI), 1H-Pyrazole-5-carboxamide, 4-Hydroxy-3-beta-D-ribofuranosyl- (9CI) 
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of… (More)
National Institutes of Health

Papers overview

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2009
2009
A series of novel 3-aryl-1-arylmethyl-1H-pyrazole-5-carboxamide derivatives 3a-l, were synthesized by the reaction of 3-aryl-1… (More)
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Highly Cited
2003
Highly Cited
2003
The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been… (More)
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Highly Cited
2002
Highly Cited
2002
The recent West Nile virus (WNV) outbreak in the United States has increased the need to identify effective therapies for this… (More)
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2000
2000
Pyrazofurin (PZF), a cytidine analog and an inhibitor of orotate monophosphate decarboxylase, has been shown to decrease the… (More)
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1991
1991
Acyclic analogues of pyrazofurin, including 4-hydroxy-3(5)-[( 2-hydroxy-1-(hydroxymethyl)-ethoxy]methyl)-1H-pyrazole-5 (3… (More)
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1986
1986
The effect of pyrazofurin, an inhibitor of UMP synthesis, on Plasmodium falciparum growth in vitro has been studied. ID50 values… (More)
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1982
1982
The antibiotic pyrazofurin, 3-(beta-D-ribofuranosyl)-4-hydroxypyrazole-5-carboxamide, markedly inhibited the in vitro replication… (More)
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1981
1981
In the reaction adenosine + L-homocysteine = S-adenosyl-L-homocysteine, catalyzed by S-adenosylhomo-cysteine hydrolase from beef… (More)
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1980
1980
Pyrazofurin, an inhibitor of orotidylate decarboxylase, imposes an absolute nutritional requirement for exogenous uridine to… (More)
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1979
1979
The 5'-phosphate derivative of the C-nucleoside pyrazofurin (ßanomer) is a competitive inhibitor of orotidylate decarboxylase… (More)
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