Skip to search formSkip to main contentSkip to account menu

pyrazofurin

Known as: Pyrazole, -3-Carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl, 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-.beta.-D-ribofuranosyl- (9CI), 1H-Pyrazole-5-carboxamide, 4-Hydroxy-3-beta-D-ribofuranosyl- (9CI) 
A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (7)

Anti-Bacterial AgentsAntibiotics, AntineoplasticAntimetabolites, AntineoplasticAntiviral Agents

Narrower (2)

Compound 47599NSC 143095

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1988
1988
Synthesis and evaluation of 5-amino-1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase.
The 5-amino and certain related derivatives of the powerful purine nucleoside phosphorylase (PNPase) inhibitor 1-beta-D… 
1987
1987
Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase.
5-Fluorouracil, 5-fluorouridine (FUrd), 5-fluoro-2'-deoxyuridine (FdUrd), 5-fluorocytidine (FCyd), 5-fluoro-2'-deoxycytidine… 
1986
1986
Tiazofurin metabolism in human lymphoblastoid cells: evidence for phosphorylation by adenosine kinase and 5'-nucleotidase.
The exact route of metabolism of tiazofurin, a novel nucleoside with antitumor activity, is controversial. Using human cell lines… 
1985
1985
Characterization of pyrazofurin-resistant HeLa cells with amplification of UMP synthase gene
Three different phenotypes have been characterized in HeLa cells that have been selected for resistance to pyrazofurin, a potent… 
Highly Cited
1981
Highly Cited
1981
Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases.
The biochemical basis of cellular resistance to 9-beta-D-arabinofuranosyladenine (ara-A) and its natural purine derivative… 
1981
1981
Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.
Variants of the Lewis lung carcinoma were selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of… 
1977
1977
Pharmacological and biochemical effects of pyrazofurin in humans.
After administration of Pyrazofurin (PF) in a dose range of 100 to 300 mg/sq m as a single i.v. bolus in patients with cancer… 
1977
1977
Initial clinical study with pyrazofurin.
Twenty-five patients with inoperable carcinoma and lymphoma were given pyrazofurin (pf) by iv bolus at a dose level ranging from… 
1976
1976
Inhibition of de novo pyrimidine nucleotide and DNA synthesis and growth of cultured Novikoff rat hepatoma cells and other cell lines by pyrazofurin (NSC 143095).
Pyrazofurin (PYF), a C-riboside, inhibited the replication of cultured Novikoff rat hepatoma cells, HeLa cells, and mouse L-cells… 
1974
1974
Quantitative Assay of Pyrazofurin a New Antiviral, Antitumor Antibiotic
Pyrazofurin, a carbon-linked nucleoside, has been previously reported to possess antiviral and antitumor activity. The…