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prorenoate potassium

Known as: potassium prorenoate 
The potassium salt form of prorenoate, a steroidal aldosterone antagonist with potassium-sparing diuretic activity. Prorenoate antagonizes the… 
National Institutes of Health

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3 relations

Broader (1)

Spironolactone
analogs & derivativesprorenoate

Papers overview

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1995
1995
Aldosterone (ALDO) increases transmembrane influx of Na+ in vascular smooth muscle (VSM) cells through increased synthesis of Na+ channels
1989
1989
Studies on spirolactone steroid antagonists in ACTH-induced hypertension in sheep.
1982
1982
Comparison of prorenoate potassium and spironolactone after repeated doses and steady state plasma levels of active metabolites.
1 After repeated single daily doses, the aldosterone antagonists prorenoate potassium and spironolactone were compared with… 
1982
1982
Detection and comparative evaluation of aldosterone antagonists in glucocorticoid-treated, adrenalectomized rats.
1982
1982
Effect of aldosterone antagonists on mineralocorticoid synthesis in vitro. Inhibition of aldosterone production by prorenoate-K.
1981
1981
Steady‐state relative potency of aldosterone antagonists: Spironolactone and prorenoate
The dose ratio approach was used to define the steady‐state relative potency of the competitive mineralocorticoid antagonists… 
1979
1979
Comparative effects of canrenoate-k and prorenoate-k upon aldosterone biosynthesis in perifused frog interrenal glands
1976
1976
The pharmacodynamics of single doses of prorenoate potasssium and spironolactone in fludrocortisone treated normal subjects.
1 The pharmacodynamic profile of single oral doses of prorenoate potassium (40 mg) and spironolactone (100 mg), as judged by… 
1976
1976
Antagonism of endogenous mineralocorticoids in normal subjects by prorenoate potassium and spironolactone
SummaryThe pharmacological activity of single oral doses of a new aldosterone antagonist, prorenoate potassium, has been compared… 
1975
1975
Relative potency of prorenoate and spironolactone in normal man
The potency of single doses of a new aldosterone antagonist, prorenoate, in reversing the renal effects of the synthetic… 
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