• Publications
  • Influence
Hexosamines, insulin resistance, and the complications of diabetes: current status.
  • M. Buse
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 2006
The hexosamine biosynthesis pathway (HBP) is a relatively minor branch of glycolysis. Fructose 6-phosphate is converted to glucosamine 6-phosphate, catalyzed by the first and rate-limiting enzymeExpand
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The Inhibition of Islet Superoxide Dismutase by Diabetogenic Drugs
The enzyme superoxide dismutase (SOD) is a scavenger of superoxide radicals and protects the integrity of cell membranes. We previously reported that streptozotocin inhibits the SOD activity ofExpand
  • 168
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Leucine. A possible regulator of protein turnover in muscle.
  • M. Buse, S. Reid
  • Medicine, Biology
  • The Journal of clinical investigation
  • 1 November 1975
Incorporation of radiolabeled precursors into muscle proteins was studied in isolated rat hemidiaphragms. A mixture of three branched-chain amino acids (0.3 mM each) added to media containing glucoseExpand
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High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes.
Sustained hyperglycemia induces insulin resistance, but the mechanism is still incompletely understood. Glucosamine (GlcN) has been extensively used to model the role of the hexosamine synthesisExpand
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Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons*
In addition to microvascular abnormalities, neuronal apoptosis occurs early in diabetic retinopathy, but the mechanism is unknown. Insulin may act as a neurotrophic factor in the retina via theExpand
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Effects of Diabetes and Hyperglycemia on the Hexosamine Synthesis Pathway in Rat Muscle and Liver
In vitro studies suggested that increased flux of glucose through the hexosamine biosynthesis pathway (HexNSP) contributes to glucose-induced insulin resistance. Glutamine:fructose-6-Expand
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Effect of denervation on the expression of two glucose transporter isoforms in rat hindlimb muscle.
Denervation rapidly (within 24 h) induces insulin resistance of several insulin-responsive pathways in skeletal muscle, including glucose transport; resistance is usually maximal by 3 d. We examinedExpand
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Identification of the Major Site of O-Linked β-N-Acetylglucosamine Modification in the C Terminus of Insulin Receptor Substrate-1 *S
Signal transduction from the insulin receptor to downstream effectors is attenuated by phosphorylation at a number of Ser/Thr residues of insulin receptor substrate-1 (IRS-1) resulting in resistanceExpand
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O-Linked N-Acetylglucosamine Modification of Insulin Receptor Substrate-1 Occurs in Close Proximity to Multiple SH2 Domain Binding Motifs*
Insulin receptor substrate-1 (IRS-1) is a highly phosphorylated adaptor protein critical to insulin and IGF-1 receptor signaling. Ser/Thr kinases impact the metabolic and mitogenic effects elicitedExpand
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A novel variant of glutamine: fructose-6-phosphate amidotransferase-1 (GFAT1) mRNA is selectively expressed in striated muscle.
Glutamine:fructose-6-phosphate amidotransferase(GFAT) is the rate-limiting enzyme of the hexosamine synthesis pathway. Products of this pathway have been implicated in insulin resistance and glucoseExpand
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