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propildazine

Known as: 3-hydrazino-6-((2-hydroxypropyl)methylamino)pyridazine, PILDRALAZINE, propyldazine 
National Institutes of Health

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Pyridazines

Papers overview

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2004
2004
Carcinogenicity study in mice on pildralazine, a hydralazinelike antihypertensive compound
SummaryPildralazine, a hydralazinelike antihypertensive vasodilator containing a free hydrazine group, was administered in the… 
1987
1987
Kinetic studies of the tissue binding tendency of the new vasodilator pildralazine.
Studies of the binding and release of the new antihypertensive drug (+/-)-1-[(6-hydrazinopyridazin-3-yl)methylamino]-2-propanol… 
1986
1986
Effects of long-term administration of propyldazine on blood pressure and counter-regulatory systems in conscious hypertensive dogs.
The counter-regulatory effects in response to blood pressure reduction by propyldazine were studied in conscious dogs with… 
1985
1985
Propyldazine is mutagenic in Salmonella typhimurium and Escherichia coli: distinct specificity for strains TA1537 and TA97.
  • H. GlattF. Oesch
  • Teratogenesis, carcinogenesis, and mutagenesis…
  • 1985
  • Corpus ID: 21826791
The antihypertensive drug propyldazine (Atensil) was demonstrated to be mutagenic with auxotrophic mutants of Salmonella… 
1985
1985
Characterization of vasodilators by comparison of their effects on blood pressure, counterregulation and myocardial oxygen demand in conscious normotensive dogs.
Vasodilators were characterized on the basis of their first-dose effect on systolic and diastolic blood pressure, heart rate, on… 
1984
1984
Effects of pildralazine alone and in combination on severe hypertension and cerebrovascular lesions in saline-drinking spontaneously hypertensive rats.
The efficacy of long-term treatments with the vasodilator antihypertensive pildralazine alone and in combination with propranolol… 
1984
1984
Altered blood pressure response to propyldazine after repeated oral administration in conscious normotensive dogs: role of the renin-angiotensin system
SummaryThe magnitude and the persistence of blood pressure reduction by propyldazine (PDZ) was investigated following treatment… 
1981
1981
Degradation of propildazine in water.
Propildazine degradation in water at pH 7.4 was studied under aerobic conditions. Three main products were isolated by column… 
1979
1979
[Treatment of severe arterial hypertension with propyldazine (ISF 2123) associated with a diuretic and a beta-blocking agent].
1978
1978
Quantitative determination of propildazine in rat plasma by gas-liquid chromatography.
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