profilin 1

Known as: Profilin I, Profilin-1 
 
National Institutes of Health

Related topics

Related topics

3 relations
PFN1 gene

Narrower (1)

PFN1 protein, human

Broader (1)

Profilins

Papers overview

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Highly Cited
2015
Highly Cited
2015
Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.
Cells contain multiple F-actin assembly pathways, including the Arp2/3 complex, formins, and Ena/VASP, which have largely been… (More)
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2014
2014
Profilin-1 Phosphorylation Directs Angiocrine Expression and Glioblastoma Progression through HIF-1α Accumulation
The tumour vascular microenvironment supports tumorigenesis not only by supplying oxygen and diffusible nutrients but also by… (More)
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Highly Cited
2012
Highly Cited
2012
Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.
Dynamic actin cytoskeletal reorganization is integral to cell motility. Profilins are well-characterized regulators of actin… (More)
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2012
2012
Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
Angiogenesis, the formation of new blood vessels, is fundamental to development and post-injury tissue repair. Vascular… (More)
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2012
2012
Protein Phosphatase 1 Dephosphorylates Profilin-1 at Ser-137
Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target… (More)
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Highly Cited
2009
Highly Cited
2009
Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.
We previously showed that silencing profilin-1 (Pfn1) expression increases breast cancer cell motility, but the underlying… (More)
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Highly Cited
2007
Highly Cited
2007
Profilin-1 is a negative regulator of mammary carcinoma aggressiveness
Expression of profilin-1 (Pfn1) is downregulated in breast cancer cells, the functional significance of which is yet to be… (More)
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2007
2007
Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse.
Atherosclerosis-related events are a major cause of morbidity and death worldwide, but the mechanisms underlying atherogenesis… (More)
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Highly Cited
2006
Highly Cited
2006
Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis.
Expression of several actin-binding proteins including profilin-1 is up-regulated during capillary morphogenesis of endothelial… (More)
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1993
1993
Cloning and expression of a novel human profilin variant, profilin II.
We have isolated a 1.7 kbp cDNA encoding a 140 amino acid protein (15.1 kDa, pI 5.91) with a high sequence similarity (62%) to… (More)
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