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Propagation of Tau Misfolding from the Outside to the Inside of a Cell*
Tauopathies are neurodegenerative diseases characterized by aggregation of the microtubule-associated protein Tau in neurons and glia. Although Tau is normally considered an intracellular protein,Expand
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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
Prion-like propagation of tau aggregation might underlie the stereotyped progression of neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in vivo that linkExpand
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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
Significance Prion-like propagation of proteopathic seeds may underlie the progression of neurodegenerative diseases, including the tauopathies and synucleinopathies. Aggregate entry into the cell isExpand
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Proteopathic tau seeding predicts tauopathy in vivo
Significance Prion-like propagation of proteopathic seeds may underlie the progression of neurodegenerative diseases, including the tauopathies and synucleinopathies. We aimed to construct aExpand
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In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice
Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tauExpand
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The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions.
Nuclear receptors (NRs) are ligand-regulated transcription factors important in human physiology and disease. In certain NRs, including the androgen receptor (AR), ligand binding to theExpand
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Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation
ABSTRACT Y-27632, an inhibitor of the Rho-associated kinase ROCK, is a therapeutic lead for Huntington disease (HD). The downstream targets that mediate its inhibitory effects on huntingtin (Htt)Expand
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Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.
The mechanism by which a single factor evokes opposite regulatory effects from a specific DNA sequence is not well understood. In this study, a 25-base pair element that resides upstream of the mouseExpand
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Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
Hanneke E.M. den Ouden,1,3,* Nathaniel D. Daw,2,3 Guillén Fernandez,1,4 Joris A. Elshout,1,4 Mark Rijpkema,1 Martine Hoogman,5 Barbara Franke,1,5,6 and Roshan Cools1,6 1Donders Institute for Brain,Expand
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Trans-cellular Propagation of Tau Aggregation by Fibrillar Species*
Background: Trans-cellular propagation of aggregation may be important in neurodegeneration, but mechanisms are unknown. Results: Tau fibrils are secreted into the extracellular space, where theyExpand
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