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PFN1 protein, human

Known as: Profilin I, Epididymis Tissue Protein Li 184a, Profilin-I 
Profilin-1 (140 aa, ~15 kDa) is encoded by the human PFN1 gene. This protein plays a role in the modulation of actin polymerization.
National Institutes of Health

Related topics

Related topics

15 relations
Actin-Binding ProteinCell MovementCytokinesisCytoskeletal Gene

Broader (2)

Profilinsprofilin 1

Papers overview

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2018
2018
Role of GSPE in improving early cerebral vascular damage by inhibition of Profilin-1 expression in a ouabain-induced hypertension model.
OBJECTIVE Grape seed proanthocyanidin extract (GSPE), as one of the most popular natural drug extracted from the grape, has been… 
2017
2017
Self-Assembly of Human Profilin-1 Detected by Carr-Purcell-Meiboom-Gill Nuclear Magnetic Resonance (CPMG NMR) Spectroscopy.
Protein oligomerization in the cell has important implications for both health and disease, and an understanding of the… 
2017
2017
Downregulation of Profilin-1 Expression Attenuates Cardiomyocytes Hypertrophy and Apoptosis Induced by Advanced Glycation End Products in H9c2 Cells
Cardiomyocytes hypertrophy and apoptosis induced by advanced glycation end products (AGEs) is the crucial pathological foundation… 
2015
2015
Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-suppressive Activity of Profilin-1*
Background: The actin-binding protein profilin-1 is a eukaryotic protein essential for growth, with poorly understood antitumor… 
2014
2014
Actin Filaments at the Leading Edge of Cancer Cells Are Characterized by a High Mobile Fraction and Turnover Regulation by Profilin I
Cellular motility is the basis for cancer cell invasion and metastasis. In the case of breast cancer, the most common type of… 
2014
2014
A High-Content, Multiplexed Screen in Human Breast Cancer Cells Identifies Profilin-1 Inducers with Anti-Migratory Activities
Profilin-1 (Pfn-1) is a ubiquitously expressed actin-binding protein that is essential for normal cell proliferation and… 
2006
2006
Profilin-I-ligand interactions influence various aspects of neuronal differentiation
Differentiating neurons extend membrane protrusions that develop into growing neurites. The driving force for neurite outgrowth… 
2005
2005
Use of transduction proteins to target trabecular meshwork cells: outflow modulation by profilin I.
PURPOSE Fusion proteins containing a protein transduction domain (PTD4) are able to cross biological membranes. We tested the… 
Highly Cited
1997
Highly Cited
1997
Cloning and expression of the panallergen profilin and the major allergen (Ole e 1) from olive tree pollen.
Highly Cited
1991
Highly Cited
1991
Dictyostelium discoideum contains two profilin isoforms that differ in structure and function.
Two profilin isoforms (profilins I and II) have been purified from Dictyostelium discoideum, using affinity chromatography on a… 
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