Profilin-I-ligand interactions influence various aspects of neuronal differentiation.

@article{Lambrechts2006ProfilinIligandII,
  title={Profilin-I-ligand interactions influence various aspects of neuronal differentiation.},
  author={Anja Lambrechts and Veronique Jonckheere and Christa Peleman and Debby Polet and Winnok H. De Vos and Jo{\"e}l Vandekerckhove and Christophe Ampe},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 8},
  pages={
          1570-8
        }
}
Differentiating neurons extend membrane protrusions that develop into growing neurites. The driving force for neurite outgrowth is the dynamic actin cytoskeleton, which is regulated by actin-binding proteins. In this study, we describe for the first time, the role of profilin I and its ligand interactions in neuritogenesis of PC12 cells. High-level overexpression of wild-type profilin I had an inhibitory effect on neurite outgrowth. Low levels of profilin I did not disturb this process, but… CONTINUE READING

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