Skip to search formSkip to main contentSkip to account menu

PFN1 gene

Known as: PFN1, PROFILIN 1, Profilin 1 Gene 
This gene plays a role in the regulation of actin polymerization.
National Institutes of Health

Related topics

Related topics

5 relations
Cytoskeletal ModelingLigand BindingPFN1 protein, humanSignal Transduction Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants
Mutations in the profilin 1 (PFN1) gene are causative for familial amyotrophic lateral sclerosis (fALS). However, it is still not… 
2017
2017
MiR‐19 regulates breast cancer cell aggressiveness by targeting profilin 1
The above article from FEBS Letters, published online on 19 April 2017 in Wiley Online Library (http://wileyon linelibrary.com… 
2015
2015
Subcellular Localization and Ser-137 Phosphorylation Regulate Tumor-suppressive Activity of Profilin-1*
Background: The actin-binding protein profilin-1 is a eukaryotic protein essential for growth, with poorly understood antitumor… 
2013
2013
Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.
The correlation between the loss of Profilin 1 (Pfn1) with tumor progression indicated that Pfn1 is a tumor suppressor in human… 
2013
2013
Mutations in the profilin 1 gene are not common in amyotrophic lateral sclerosis of Chinese origin
2010
2010
Mobilization and prevalence of a Fusobacterial plasmid.
2009
2009
Down-regulation of microfilamental network-associated proteins in leukocytes of breast cancer patients: potential application to predictive diagnosis.
BACKGROUND Breast cancer is one of the most frequent tumors worldwide. Currently applied diagnostic approaches are frequently not… 
2009
2009
Structure, modifications and ligand-binding properties of rat profilin 2a.
Profilins are key regulators of the actin microfilament system and in neuronal tissues the profilin 2a isoform is the most… 
2007
2007
HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics.
Review
2005
Review
2005
Interactions Between Vacuolar H+-ATPases and Microfilaments in Osteoclasts
 Vacuolar H+-ATPases (V-ATPases) are transported from cytosolic compartments to the ruffled plasma membrane of osteoclasts as… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)