prinomastat

Known as: (3S)-N-Hydroxy-2,2-dimethyl-4-{{4-(4-piridinyloxy)phenyl}sulfonyl}-3-thiomorpholinecarboxamide 
A synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically… (More)

Topic mentions per year

Topic mentions per year

2000-2015
0246820002015

Papers overview

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2012
2012
Human cytochrome P450 2D6 contributes to the metabolism of >15% of drugs used in clinical practice. This study determined the… (More)
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2005
2005
PURPOSE Matrix metalloproteinases (MMPs) degrade extracellular proteins and facilitate tumor growth, invasion, metastasis, and… (More)
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2004
2004
Photodynamic therapy (PDT) clinical results are promising; however, tumor recurrences can occur and, therefore, methods for… (More)
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2004
2004
PURPOSE Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of… (More)
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Highly Cited
2004
Highly Cited
2004
Advanced stages of neuroblastoma show increased expression of matrix metalloproteinases MMP-2 and MMP-9, that have been… (More)
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2003
2003
Membrane type-1 matrix metalloproteinase (MT1-MMP) and alphavbeta3 integrin have been directly implicated in tumor cell… (More)
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2002
2002
PURPOSE We studied the effects of intravitreally administered prinomastat on the take rate and growth of uveal melanoma after… (More)
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Highly Cited
2001
Highly Cited
2001
A number of different matrix metalloproteinase (MMP) inhibitors have been developed as cytostatic and anti-angiogenic agents and… (More)
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Highly Cited
2001
Highly Cited
2001
Mechanical ventilation has become an indispensable therapeutic modality for patients with respiratory failure. However, a serious… (More)
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2000
2000
PURPOSE To determine the efficacy of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinase, in the treatment of… (More)
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