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prinomastat

Known as: (3S)-N-Hydroxy-2,2-dimethyl-4-{{4-(4-piridinyloxy)phenyl}sulfonyl}-3-thiomorpholinecarboxamide 
A synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

Ag 3340

Broader (2)

Matrix Metalloproteinase InhibitorsOrganic Chemicals

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Human CYP 2 D 6 Structure 1 CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P 450 2 D 6 WITH PRINOMASTAT BOUND
Address correspondence to: Eric F. Johnson, Dept. of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N… 
2009
2009
Inhibition of gelatinase activity reduces neural injury in an ex vivo model of hypoxia–ischemia
Highly Cited
2008
Highly Cited
2008
Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat
BackgroundHypoxia-ischemia (H-I) can produce widespread neurodegeneration and deep cerebral white matter injury in the neonate… 
2006
2006
Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma
SummaryPurpose: This randomized phase II, parallel-design study evaluated preoperative combined modality therapy and the matrix… 
2004
2004
Magnetic Resonance Imaging Detects Early Changes in Microvascular Permeability in Xenograft Tumors after Treatment with the Matrix Metalloprotease Inhibitor Prinomastat
Macromolecular contrast medium-enhanced magnetic resonance imaging was applied to monitor the effect of matrix metalloprotease… 
2004
2004
THE EFFECT OF PRINOMASTAT (AG3340), A POTENT INHIBITOR OF MATRIX METALLOPROTEINASE, ON A NEW ANIMAL MODEL OF EPIRETINAL MEMBRANE
Purpose: To develop a simple epiretinal membrane (ERM) animal model and evaluate the efficacy of prinomastat (AG3340), a… 
Review
2003
Review
2003
Angiogenesis inhibitors under study for the treatment of lung cancer.
Review
2001
Review
2001
Angiogenesis inhibitors in the treatment of lung cancer.
2001
2001
Inhibitory effect of a matrix metalloproteinase inhibitor on growth and spread of human pancreatic ductal adenocarcinoma evaluated in an orthotopic severe combined immunodeficient (SCID) mouse model.
2000
2000
The Effect of Prinomastat (AG3340), a Synthetic Inhibitor of Matrix Metalloproteinases, on Posttraumatic Proliferative Vitreoretinopathy
In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we… 
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