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Blockade of adrenoreceptors inhibits the splenic response to stroke
Recent studies have highlighted the involvement of the peripheral immune system in delayed cellular degeneration after stroke. In the permanent middle cerebral artery occlusion (MCAO) model ofExpand
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Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension
Aggregating proteoglycans (PG) bearing chondroitin sulfate (CS) side chains associate with hyaluronan and various secreted proteins to form a complex of extracellular matrix (ECM) that inhibitsExpand
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The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling
Delayed neuronal death associated with stroke has been increasingly linked to the immune response to the injury. Splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective andExpand
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Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats
BackgroundTraumatic brain injury (TBI) evokes a systemic immune response including leukocyte migration into the brain and release of pro-inflammatory cytokines; however, the mechanisms underlying TBIExpand
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Oral administration of the flavanol (−)‐epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway
Consumption of flavan‐3‐ols, notably (−)‐epicatechin (EC), has been highly recommended in complementary and alternative medicine (CAM) due to reports that flavan‐3‐ols boost antioxidant activity,Expand
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Human umbilical cord blood cell therapy blocks the morphological change and recruitment of CD11b‐expressing, isolectin‐binding proinflammatory cells after middle cerebral artery occlusion
Secondary neurodegeneration resulting from stroke is mediated by delayed proinflammatory signaling and immune cell activation. Although it remains unknown which cell surface markers signify aExpand
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Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injury
Exposure to hypoxic-ischemic insults during the neonatal or perinatal developmental periods produces various forms of pathology. Injuries that occur in response to these events often manifest asExpand
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Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation
A major limitation of current stroke therapies is the need to treat candidate patients within 3 h of stroke onset. Human umbilical cord blood cell (HUCBC) and the sigma receptor agonist 1,3,Expand
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Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins
Abstract Epidemiological studies have demonstrated that the consumption of fruits and vegetables is associated with reduced risk for cardiovascular disease and stroke. Detailed investigations intoExpand
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Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat
BackgroundHypoxia-ischemia (H-I) can produce widespread neurodegeneration and deep cerebral white matter injury in the neonate. Resident microglia and invading leukocytes promote lesion progressionExpand
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