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pridopidine

Known as: 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine, huntexil, 4-(3-methanesulfonylphenyl)-1-propylpiperidine 
National Institutes of Health

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Piperidines

Papers overview

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2018
2018
Effects of the Dopamine Stabilizer, Pridopidine, on Basal and Phencyclidine-Induced Locomotion: Role of Dopamine D2 and Sigma-1 Receptors.
BACKGROUND Pridopidine, a compound in clinical trials for Huntington's disease treatment, was originally synthesized as a… 
2018
2018
Loss of the Sigma-1 receptor disrupts pridopidine-induced gene expression (P4.048)
Objective: Investigate the role of S1R in the mechanism of action of pridopidine. Background: Sigma-1 receptor (S1R) is an ER… 
2017
2017
Biological Insights of the Dopaminergic Stabilizer ACR16 at the Binding Pocket of Dopamine D2 Receptor.
The dopamine D2 receptor (D2R) plays an important part in the human central nervous system and it is considered to be a focal… 
2016
2016
L6 Evaluation of pridopidine in the transgenic yac128 mouse model of huntington’s disease
Pridopidine is currently in clinical development for Huntington’s disease (HD) and investigations to increase the understanding… 
2015
2015
Profile of pridopidine and its potential in the treatment of Huntington disease: the evidence to date
Huntington disease (HD) is a chronic, genetic, neurodegenerative disease for which there is no cure. The main symptoms of HD are… 
2015
2015
The effect of mild and moderate renal impairment on the pharmacokinetics of pridopidine, a new drug for Huntington's disease
Aim Pridopidine, a new oral drug for treatment of patients with motor symptoms associated with Huntington's Disease (HD) is… 
Review
2013
Review
2013
Pridopidine in the pharmacological treatment of Huntington’s disease
The available treatment options for Huntington’s disease (HD) are only symptomatic, partly with a limited symptom control and… 
2012
2012
Using molecular signals controlling embryonic development to direct the differentiation of corticospinal motor neurons
2012
2012
Q08 Potential neuroprotective effects of pridopidine in Huntington's disease
Background Huntington's disease (HD) is a neurodegenerative disorder characterised by hyperkinetic movements (chorea), cognitive… 
2010
2010
NeuroSearch announces new findings from the MermaiHD Phase III study supporting potential disease modifying properties of Huntexil
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